Project Grant R01AG092379
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $132,472 Project Grant under the Aging Research program (CFDA 93.866) to the University of Massachusetts Medical School (UMMS). The grant, with a performance period from September 4, 2025 to May 31, 2027, will support research to understand the regulation of apoptotic sensitivity (programmed cell death) in the brain during normal aging and in Alzheimer's disease and other...
- This federal Project Grant award of $3,178,675.00, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to identify the conformations and abundances of amyloid proteins, such as alpha-synuclein, inside cells in order to enhance the understanding of amyloid propagation and identify biologically relevant structures. The key research activities include investigating how different cellular environments affect seeded amyloid propagation using...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $148,050 project grant to Northwestern University to investigate sex-specific hypothalamic pathology and immune infiltration in Alzheimer's disease (AD). The project aims to utilize single-cell fixed RNA profiling to identify and evaluate cell-specific transcriptomic alterations in the AD hypothalamus, as well as explore how altered hormonal signaling may influence neuroinflammation...
- This federal Project Grant award for $160,000.00 was provided by the National Institute on Aging (CFDA 93.866 Aging Research program) to Northwestern University from September 30, 2025 to August 31, 2027. The goal of the research is to investigate the role of depolarizing GABA in Alzheimer's disease, with a focus on understanding the cellular mechanisms of cognitive impairment and the potential for GABA signaling as a therapeutic target. The research aims to advance scientific knowledge about...
- This federal Project Grant award of $509,413.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to conduct research on the role of epitranscriptomic regulation of microglial cells in the development and progression of Alzheimer's disease (AD). The project will investigate how methylation of adenosine residues in mRNA (m6A modification) and its regulatory proteins are altered in the brains of AD patients, and how these changes impact microglial function and the brain's...
- This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research by Northwestern University to investigate synergistic approaches for enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies and Parkinson's disease-dementia. The research will use patient-derived induced pluripotent stem cell neuron models and mouse models to test the effects of...
- This $6,290,600 federal Project Grant award from the Department of Health and Human Services' National Institute on Aging (CFDA 93.866 - Aging Research) will fund a comprehensive, multi-year research project to investigate the regulation of the proteasome complex in neurodegenerative diseases. The research will utilize integrated multi-omics and functional approaches to elucidate how the ubiquitin-proteasome system is affected in Alzheimer's disease, progressive supranuclear palsy, Parkinson's...
- The National Institutes of Health (NIH) National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded The Johns Hopkins University a $480,710 Project Grant titled "Investigating a Novel Vascular Pathway that Regulates Neuronal Survival." The grant, awarded on September 5, 2025, supports research to investigate a novel signaling pathway in vascular endothelial cells that releases a protein required for neuronal survival, with the goal of...
- The University of Massachusetts Medical School (UMass Medical) was awarded a $1,507,500 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) to conduct a study on spatial single-cell analysis of somatic mutations in the human brain during aging and neurodegeneration. The goal is to develop and apply new single-cell whole-genome sequencing methods to study somatic mutations in neurons from late-stage Alzheimer's disease and...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,851,569.00 in funding to The Washington University to conduct research on how early brain development informs later neurodegeneration, with a focus on Alzheimer's disease. The project aims to determine if regions of the brain with high plasticity during early development are more susceptible to pathological changes later in life, and if adverse developmental conditions have...
This federal Project Grant award of $457,112 was provided by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The award supports research at Northwestern University to investigate a powerful cell death mechanism known as DISE (Death Induced by Survival Elimination) and its potential links to neurodegenerative diseases like Huntington's and Alzheimer's. Key objectives include understanding how overactive DISE or loss of protective mechanisms could contribute to pathology in affected tissues, and exploring the hypothesis that many neurodegenerative diseases have a toxic RNA component. The 5-year project period runs from January 1, 2026 to December 31, 2030 and is expected to provide important insights into the biological underpinnings of age-related neurological disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $457.1k | 12/30/25 |