This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,368,557.00 over the period of March 15, 2025 to January 31, 2030 to a research partnership between Henry Ford Health and Michigan State University Health Sciences. The project aims to identify links between pesticide exposure and markers across the Alzheimer's disease and related dementias (ADRD) neurodegeneration continuum, from preclinical biomarkers to clinical diagnosis. The study will leverage 30 years of environmental health data from the Agricultural Health Study (AHS) cohort and conduct longitudinal cognitive, olfactory, and motor assessments in a sub-cohort of 2,545 AHS farmers aged 50-79. The research will involve collecting blood samples, assessing cognitive function, olfaction, gustation, and motor skills at multiple time points to determine the association between pesticide exposures and ADRD development. The findings from this comprehensive study are expected to advance the understanding of the role of ubiquitous environmental exposures in various stages of ADRD and inform future prevention strategies.
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