The University of Illinois was awarded a $794,341 Project Grant under the National Institute on Aging's Aging Research program (CFDA 93.866) to conduct research on pathogen-induced cellular senescence and blood-brain barrier dysfunction in Alzheimer's disease. The project aims to investigate how viral and bacterial infections can initiate blood-brain barrier dysfunction and promote Alzheimer's disease progression through increased cellular senescence and inflammatory signaling. The research will leverage experimental mouse models, single-cell transcriptomics, and human induced pluripotent stem cell models to elucidate the mechanistic links between pathogens, cellular senescence, and blood-brain barrier impairment in Alzheimer's disease. This 5-year grant, awarded on January 1, 2025, will provide critical insights into the role of infections and cellular senescence in the development and progression of Alzheimer's disease.
Generated 1/28/25, 7:03 AM