The University of Southern California (USC) Department of Contracts and Grants Division is receiving a $594,041 Project Grant award from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The project aims to comprehensively measure phosphorylated tau protein (p-tau217) in plasma samples from the Health and Aging Brain Study-Health Disparities (HABS-HD) cohort, which includes Hispanic, African American, and non-Hispanic White populations. The goal is to determine plasma biomarker cutoffs relevant to ethnicity and race for detecting Alzheimer's disease pathology, as measured by amyloid PET imaging. The research team will also investigate how other Alzheimer's disease hallmarks, such as the amyloid-beta 42/40 ratio, are associated with p-tau217 levels in these diverse populations. This five-year project aims to document the biomarker profiles for the HABS-HD cohort and explore whether amyloid PET scans can be reduced in the screening process for certain populations.
Generated 3/4/25, 8:40 AM