Project Grant R01AG088264
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $388,750 to The Washington University to conduct research on the role of senescent cancer-associated fibroblasts (senCAFs) in breast cancer progression. The key objectives are to: 1) Determine the organ-specific effects of senCAFs on metastatic breast cancer progression; 2) Examine how senCAFs impact extracellular matrix dynamics and tumor cell migration; and 3) Assess the impact of senCAFs on...
- This $2,638,738.00 Project Grant award from the National Cancer Institute (CFDA 93.396 - Cancer Biology Research) supports research to understand how aging increases the metastatic competence of the omentum, a fatty tissue that is a common site of metastasis in ovarian cancer. The research aims to identify the mechanisms by which aging increases the accumulation of immunosuppressive innate-like B cells in the omentum, and to develop strategies to decrease the metastatic competence of the omentum...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $624,000.00 to the University of Texas Health Science Center at Houston to explore a patient priorities care framework for improving breast cancer survivorship care for older women with multiple chronic conditions. The project aims to use this framework to identify patient priorities, incorporate them into treatment plans, and evaluate the feasibility and impact on treatment burden and quality...
- This federal Project Grant award of $1,033,055.00 was provided by the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The funding supports research aimed at understanding and targeting the mechanisms of cancer metastasis. The project, titled "Targeting Cancer Metastasis by Inhibiting Curvature-Induced Kinase Activation," seeks to unravel the molecular pathways underlying how cancer cells acquire the...
- This federal Project Grant award of $3,101,237.00 was provided by the National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The funding supports a research project investigating the mechanisms linking persistent DNA damage to immune responses and hematopoietic stem and progenitor cell function in the context of aging and DNA repair deficiency. Key objectives of the project include: 1) elucidating...
- This federal Project Grant award of $204,474, awarded by the National Cancer Institute (CFDA 93.398 Cancer Research Manpower program), is supporting research to define the transition from deep cell quiescence to senescence. The University of Colorado, the awardee, will use time-lapse microscopy and molecular assays to investigate the mechanisms controlling quiescence depth and the relationship between deep quiescence and senescence. The research aims to determine if senescence is a form of...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research program (CFDA 93.866), provides $589,106 to support research on chemotherapy-induced peripheral neuropathy (CIPN). The objective is to elucidate how cellular senescence drives CIPN and impedes axonal repair, with a focus on identifying senescent cells in the peripheral nervous system and their secretory mechanisms that contribute to this condition. The 5-year project, commencing June 1, 2025, will...
- This $393,750.00 Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund a 5-year research project to explore the fundamental cellular mechanisms driving cellular senescence in macrophages. The key objectives of this research project are to gain a deeper understanding of the cellular and molecular mechanisms underlying senescent macrophage biology. This includes investigating the roles...
- This Project Grant award from the National Cancer Institute (CFDA 93.398 Cancer Research Manpower) provides $176,040.00 to The General Hospital Corporation (doing business as Massachusetts General Hospital) to conduct research on the effects of aging on CDC1 function and CD8 T cell immunity in tumors. The research aims to gain a better understanding of how age-related declines in immune function can impact the effectiveness of CD8+ T cell immunity and immunotherapy response in older cancer...
- The National Cancer Institute (CFDA 93.396 - Cancer Biology Research) awarded a $510,431 Project Grant to The Johns Hopkins University to conduct research on recurrence and resistance in the aging melanoma microenvironment. The research aims to uncover how the aging immune microenvironment influences tumor dormancy and therapeutic resistance in melanoma. Key focus areas include understanding the role of aged lung fibroblasts and their impact on melanoma cell dormancy and reactivation through Wnt...
This Project Grant award of $576,723.00 was provided by the National Institute on Aging (NIA), a component of the U.S. Department of Health and Human Services, under the Aging Research federal grant program (CFDA 93.866). The award supports research to investigate the role of senescent cancer-associated fibroblasts (SenCAFs) in the progression of breast cancer, particularly in older individuals. Key objectives include determining the organ-specific effects of SenCAFs on metastatic breast cancer progression, understanding how SenCAFs impact extracellular matrix dynamics and tumor cell migration, and evaluating the impact of SenCAFs on immune responses. The research will leverage state-of-the-art immunological and biophysical techniques, as well as novel genetically engineered mouse models and human breast cancer specimens. This 5-year project, with an award date of August 5, 2025 and ultimate completion date of April 30, 2030, is being conducted by The Washington University in Missouri.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 8/14/25 | ||
| Not listed | $576.7k | 8/4/25 |