This $1,707,089 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research by Northwestern University to investigate synergistic approaches for enhancing endoplasmic reticulum (ER) proteostasis, protein trafficking, and lysosomal activity as potential treatments for dementia with Lewy bodies and Parkinson's disease-dementia. The research will use patient-derived induced pluripotent stem cell neuron models and mouse models to test the effects of...
The National Institute on Aging awarded a $1,931,965 Project Grant (CFDA 93.866 - Aging Research) to the Regenerative Research Foundation, a non-profit organization in Albany, New York. The purpose of this federal grant is to develop and validate a novel human induced pluripotent stem cell (iPSC) model that incorporates cerebral cortical neurons, glia, vascular endothelial cells, and microglia to study cerebrovascular interactions in Alzheimer's disease-related dementias (ADRD). The R61 phase of...
This $424,875.00 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund a comprehensive study of gene transcription patterns in diverse classes of neurons that connect the brain to the spinal cord after spinal cord injury in a mouse model. The research team at Marquette University will use single-cell sequencing technologies to profile...
This federal Project Grant award of $460,500 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) is aimed at developing novel bioprinting methodologies for the production of human stem cell-based organoids. The key objectives are to: 1) Create a customized bioink formulation using proteins, polysaccharides, and functionalized nanoparticles to foster the...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,102,269 to the University of Illinois to conduct research aimed at understanding the relationship between precocious neuronal differentiation and early-onset neurodegeneration. The project will utilize the C. elegans model system to investigate how heterochronic gene mutations, such as lin-41 and lin-14, that cause precocious neuronal differentiation can subsequently lead to early-onset...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $164,648 to Trustees of Indiana University (Indianapolis) to investigate the role of the fractalkine axis in Alzheimer's disease pathology using human induced pluripotent stem cells. The central goal is to utilize human iPSCs to study the impact of the CX3CR1 V249I variant on microglial function and whether this variant induces a neurodegenerative phenotype in neurons. The research aims to...
This federal Project Grant award of $598,952.00 was provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program. The grant will fund the development of a novel human stem cell-derived multi-cellular model to study the developmental processes underlying spinal cord midline crossing of axons. The awardee, The Leland Stanford Junior University, will generate and...
This $205,619 Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to map the landscape of the aged human brain and model neurodegenerative diseases like Alzheimer's. The University of Washington will apply explainable AI methods to human brain datasets to identify molecular drivers of brain aging, then manipulate these drivers in human induced pluripotent stem cell (iPSC) models to generate aging phenotypes in neurons and glia. This two-phase...
This Project Grant award of $2,683,965.00 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program will fund the development and optimization of an "all-human cellular system" for studying Alzheimer's disease (AD) and age-related dementias (ADRDs). The primary objectives are to: 1) define delivery conditions for introducing patient blood cells and plasma into a...
This Project Grant award from the National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) program, aims to identify novel biomarkers for early diagnosis and prognosis of Alzheimer's disease (AD). The $412,500 award to the University of South Florida will be used to determine brain extracellular matrix (ECM) composition changes during normal aging and in AD, in both rodents and humans, using a decellularization-based proteomic approach. The 2-year project period runs from June...