The Leland Stanford Junior University (Stanford University) has been awarded a $1,000,000 Project Grant from the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866). The funding will support research aimed at understanding the cross-talk between skeletal stem cells (SSCs) and hematopoietic stem cells (HSCs), and whether rejuvenating SSCs can be used as a therapy to reverse age-related atherosclerotic cardiovascular disease. The project seeks to characterize the effects of SSC aging on the vasculature, including the perivascular fat, and determine if targeted reversal of age-related decreases in BMP2 signaling in SSCs can alter atherosclerosis progression. The research objectives are to enhance the understanding of organ system cross-talk that contributes to cardiovascular disease in aging populations and pave the way for novel treatment strategies. The award period runs from September 1, 2024 through May 31, 2029.
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