This $633,578 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the New Jersey Institute of Technology (NJIT) will support a multi-year study to characterize the white matter functional connectivity and networks in Alzheimer's disease (AD) and mild cognitive impairment (MCI) compared to typical aging. The research aims to systematically analyze resting-state functional MRI (rs-fMRI) of white matter regions, investigate associations between white matter functional connectivity and structural tracts, and develop predictive models linking white matter functional measures to clinical phenotypes in MCI and AD. This comprehensive analysis across multiple large neuroimaging datasets is expected to contribute to a better understanding of the impact of white matter structure and function on cognitive decline, and support the future application of white matter rs-fMRI for improved diagnosis, prognosis, and treatment of Alzheimer's disease.
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