Project Grant R01AG084567
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $460,844 to The Trustees of Columbia University in the City of New York to conduct the "LIFE-COURSE ACCULTURATION TRAJECTORIES AND DEMENTIA IN A MULTI-ETHNIC COHORT OF OLDER ADULTS: THE MESA ACCULTURATION AND DEMENTIA STUDY". The study aims to leverage longitudinal data from the Multi-Ethnic Study of Atherosclerosis (MESA) to identify unique life-course acculturation patterns among...
- This Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $4,035,962 to the Icahn School of Medicine at Mount Sinai to conduct a study examining unique markers and risk factors for Alzheimer's disease and related dementias (AD/ADRD) in foreign-born and native-born older Chinese Americans. The key products or services to be delivered through this 5-year project include investigating social determinants of health, sleep patterns,...
- This $4,444,978 federal Project Grant award, issued by the National Institute on Aging (CFDA 93.866 Aging Research program), supports research to characterize cognitive reserve and identify modifiable factors that promote cognitive reserve and resilience to Alzheimer's disease and related dementias (ADRD) among older adults in India, with a focus on those who lack formal education. The project aims to: 1) compare brain pathology measures and their contributions to cognition between older...
- This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $641,516 to the Huntington Medical Research Institutes (HMRI) to conduct longitudinal research examining the relationship between psychological risk factors (stress, depression, substance use) and cognitive performance in American Indian (AI) adults. The objectives are to evaluate how factors such as health-related quality of life and community connectedness may moderate these relationships,...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $840,931 to Duke University to conduct research on characterizing family structure, care utilization, and well-being among persons with Alzheimer's disease and related dementias (ADRD) in the Asian region. The research aims to identify major types of family structures and dynamics in providing care for persons with ADRD in countries such as China, India, and Singapore, where cultural...
- This $163,080 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) aims to address critical knowledge gaps in understanding the performance of plasma biomarkers for Alzheimer's disease and related dementias (ADRDs) in diverse populations. Specifically, the project will: Identify demographic, lifestyle, genetic, and systemic disease factors associated with elevated ADRD plasma biomarkers in population-based cohorts in the U.S. (Framingham Heart Study, n=2,543)...
- This Project Grant award from the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) provides $1,550,462 to support a 5-year cross-sectional, longitudinal, and observational study investigating the impact of Alzheimer's disease (AD) risk genes, with a focus on APOE E4, on brain function in older Black/African American individuals living with HIV. The project aims to enroll 120 participants with HIV (60 with and 60 without the APOE E4 allele) and 80 demographically...
- This Project Grant award of $131,813 from the National Institute on Aging (CFDA 93.866 Aging Research) supports research to quantify the effects of poverty alleviation policies on the risk and disparities of Alzheimer's disease and related dementias (AD/ADRD). The award recipient, Trustees of Boston University, will leverage quasi-experimental variation across U.S. states and countries to evaluate the impacts of programs like the Supplemental Nutrition Assistance Program (SNAP) and social...
- The National Institute on Aging (CFDA 93.866 - Aging Research) awarded a $433,125 project grant to the University of California, Los Angeles (UCLA) to develop and evaluate a culturally adapted sleep intervention program for older Korean immigrants with poor sleep. The 2-year project aims to refine an existing cognitive behavioral therapy for insomnia (CBTI) program to better address the cultural influences on sleep habits of this population. In Year 1, UCLA will work with stakeholders to adapt...
COGNITIVE DECLINE AND DEMENTIA IN OLDER KERALA AMERICANS - ASIAN AMERICANS (INCLUDING INDIAN AMERICANS) COMPRISE 6% OF THE U.S. POPULATION AND REPRESENT THE FASTEST GROWING POPULATION GROUP. THE INCIDENCE OF MILD COGNITIVE IMPAIRMENT AND ALZHEIMER'S DISEASE IS HIGHER AMONG RACIAL/ETHNIC MINORITIES, ESPECIALLY IN FIRST-GENERATION IMMIGRANTS. IMMIGRANT POPULATIONS SPEND A GREATER PROPORTION OF THEIR LATER YEARS WITH COGNITIVE IMPAIRMENT AND DEMENTIA THAN NATIVE BORN U.S. POPULATIONS. YET, THERE ARE FEW EPIDEMIOLOGICAL AND BIOLOGICAL STUDIES OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS IN IMMIGRANT POPULATIONS SUCH AS INDIAN AMERICANS. IN THIS FIRST OF ITS KIND STUDY, WE PROPOSE TO CLINICALLY AND BIOLOGICALLY PHENOTYPE 400 OLDER FIRST-GENERATION IMMIGRANTS FROM THE SOUTHERN INDIAN STATE OF KERALA RESIDING IN THE TRI-STATE AREA (NEW YORK, NEW JERSEY, AND CONNECTICUT) TO BETTER UNDERSTAND RISK AND PROTECTION AGAINST ALZHEIMER'S DISEASE AND RELATED DEMENTIAS IN THIS FAST-GROWING U.S. POPULATION SEGMENT. WE ALSO HAVE AN UNIQUE OPPORTUNITY TO COMPARE KERALA AMERICAN FIRST-GENERATION IMMIGRANTS WITH A NATIVE KERALA BASED COHORT OF 800 OLDER ADULTS IN OUR NIH FUNDED KERALA-EINSTEIN STUDY. THIS CROSS-NATIONAL STUDY OF A SINGLE RACIAL/ETHNIC GROUP FROM KERALA IN NATIVE AND IMMIGRANT SETTINGS USING THE SAME PROTOCOLS WILL REDUCE VARIABILITY AND ENHANCE DISCOVERY OF ALZHEIMER'S DISEASE AND DEMENTIA MECHANISMS. WE HYPOTHESIZE THAT IMMIGRATION RELATED SOCIOCULTURAL FACTORS IN OLDER KERALA AMERICANS WILL INFLUENCE BIOLOGICAL/VASCULAR AGING, WHICH IN TURN WILL IMPACT COGNITION. AIM 1: DETERMINE ROLE OF IMMIGRANT/CULTURAL FACTORS AND SOCIAL RELATIONSHIPS (NETWORKS AND SUPPORT) THAT CONTRIBUTE TO ALZHEIMER'S DISEASE AND DEMENTIA RISK IN OLDER KERALA AMERICANS. IMMIGRANT/CULTURAL FACTORS INCLUDE AGE AT MIGRATION, RESIDENCY DURATION, MIGRATION REASONS, SEX, EDUCATION, ACCULTURATION, ETC. PRIMARY OUTCOME IS GLOBAL COGNITION (ADDENBROOKE'S COGNITIVE EXAMINATION: ACE). SECONDARY OUTCOMES INCLUDE INDIVIDUAL COGNITIVE DOMAINS, MOOD (DEPRESSIVE SYMPTOMS, ANXIETY) AND QUALITY OF LIFE. TO ADDRESS THE 'HEALTHY MIGRANT' EFFECT, WE WILL EXAMINE COPING AND RESILIENCE MECHANISMS THAT MAY HELP PRESERVE COGNITION. AIM 2: DETERMINE THE CONTRIBUTION OF IMMIGRANT/CULTURAL FACTORS AND SOCIAL RELATIONSHIPS TO BIOLOGICAL AGING IN OLDER KERALA AMERICANS. BIOLOGICAL AGING IS QUANTIFIED USING EPIGENETIC CLOCKS. AIM 3: DETERMINE THE IMPACT OF IMMIGRANT/CULTURAL FACTORS AND SOCIAL RELATIONSHIPS ON VASCULAR AGING IN OLDER KERALA AMERICANS. OUTCOMES INCLUDE CARDIOVASCULAR (BP/ ELECTROCARDIOGRAM) AND CEREBROVASCULAR DISEASE INDICES (MRI SMALL VESSEL DISEASE). WE WILL COMPARE U.S. AND KERALA COHORTS ON VASCULAR AGING. OUR PROPOSAL IS VERY RESPONSIVE TO NOT-HL-23-001, WHICH SEEK APPLICATIONS TO UNDERSTAND HEALTH IN ASIAN AMERICANS. STUDYING KERALA AMERICANS CAN PROVIDE INSIGHTS INTO RISK AND PROTECTION OF ALZHEIMER'S DISEASE AND RELATED DEMENTIAS IN OTHER IMMIGRANT GROUPS WITH HIGH PREVALENCE OF CARDIOVASCULAR DISEASE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $67.0k | 9/4/25 | ||
| Not listed | $753.9k | 7/25/25 | ||
| Not listed | $753.9k | 7/25/25 | ||
| Not listed | ($754k) | 7/14/25 | ||
| Not listed | ($754k) | 7/14/25 |
GrantNumber | Description | Subgrantee | Prime Award | Dollars Obligated | Updated At |
|---|---|---|---|---|---|
312506S | The Trustees Of Columbia University In The City Of New York | Project Grant R01AG084567 | $72.8k | 6/25/24 |