This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to develop novel computational approaches to identify genetic biomarkers related to the progression of Alzheimer's disease (AD). The award to the Trustees of Indiana University, Indianapolis totals $399,345 and will be conducted from September 2024 to July 2029. The research aims to 1) identify stage-specific genetic biomarkers of AD with known effects on transcriptome and proteome layers, and 2) identify genetic biomarkers that can differentiate distinct AD phenotype trajectories. A $336,446 subaward was made to Purdue University to develop an interpretable deep learning framework for longitudinal AD diagnosis using multi-omic genetic and imaging data. The overall project seeks to improve early detection, clinical trial recruitment, and treatment assessment for this neurodegenerative disorder.
Generated 3/4/25, 8:34 AM