This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $403,500.00 in funding to Mayo Clinic to develop advanced magnetic resonance elastography (MRE) techniques for improved diagnosis and treatment prediction of normal pressure hydrocephalus (NPH). The key objectives are to: 1) Modify the MRE forward model to disentangle the effects of decreased solid tissue matrix stiffness versus increased extracellular fluid, 2) Evaluate the diagnostic accuracy of this new solid-fluid mixture MRE framework in differentiating NPH patients from healthy controls and Alzheimer's patients, and 3) Determine if baseline estimates of solid matrix stiffness can predict post-surgical gait improvement in NPH patients. The award, commencing on May 15, 2024, supports this 5-year research project aimed at advancing the biophysical understanding and clinical management of NPH, a reversible form of dementia.
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