This $570,922 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research at the University of Wisconsin - Madison to investigate the interactions between aged bone marrow microenvironments and the expansion of hematopoietic stem cells harboring the ASXL1 mutation, which is associated with increased risk of blood cancers and other diseases. The key objectives are to:
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Investigate how aged bone marrow microenvironments promote the expansion of ASXL1 mutant hematopoietic stem cells.
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Determine whether interventions targeting the aged bone marrow microenvironment and ASXL1 mutant hematopoietic cells can mitigate the expansion of these cells in older recipients.
The 5-year study aims to provide new insights into the pathogenesis, prevention, and potential treatment of nonmalignant hematologic diseases associated with clonal hematopoiesis and ASXL1 mutations. The award was granted on September 1, 2024 and is scheduled for completion on August 31, 2029.
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