Project Grant R01AG067972
- The National Institute on Aging (NIA), part of the U.S. Department of Health and Human Services, awarded a $1,249,957 Project Grant under CFDA 93.866 (Aging Research) to Advantage Therapeutics, Inc. in Florida. The grant aims to perform IND-enabling studies on a small molecule that is disease-modifying, low-cost, and has a long safety record for the treatment of Alzheimer's disease. The proposed molecule is designed to reduce brain inflammation and restore phagocytosis, thereby improving the...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund the development of a novel Alzheimer's disease therapeutic using targeted nanoparticles. The $504,732 award to Aphios Corp, a minority-owned biotechnology company, will support two phases of research. In Phase I, the company will nanoencapsulate an anti-CCR5 drug in targeted and non-targeted nanoparticles, characterize the formulations, and evaluate their impact on in vitro models of brain...
- This $2,454,521 Project Grant awarded on September 10, 2025 by the National Institute on Aging (CFDA 93.866 Aging Research) will fund the manufacturing of 2.3 kilograms of the ABCA1 agonist small molecule peptide CS6253 to support upcoming chronic toxicology studies in Wistar rats and cynomolgus monkeys. The grantee, Artery Therapeutics, Inc., will engage their trusted contract manufacturer Ambiopharm, Inc. to produce the GMP-like drug substance. This manufacturing campaign will also include...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,432,649 to Virogenics, Inc., a biotechnology company in San Diego, California, to advance the development of CMS121, an innovative drug candidate for the treatment of Alzheimer's disease (AD). The funding will support two key components: 1) A 13-week toxicology study in rats and dogs to enable longer-term clinical trials of CMS121 in human subjects with mild to moderate AD, and 2) The...
- This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $500,000.00 to Alzarrok Bio LLC to develop a peptide-based multi-target drug for Alzheimer's disease (AD). The goal is to demonstrate the in vivo efficacy of the drug candidate, ALZ100, in inhibiting neuroinflammation and neurodegeneration in an AD mouse model. The project will first determine the therapeutic concentration of ALZ100 in the brain and then evaluate its effects on key...
- This federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) provides $499,441 to Acepre, LLC to develop a novel brain-targeted delivery system for the compound N-acetylcysteine (TN-NAC) as a potential treatment for Alzheimer's disease (AD). The key objectives of this Phase I STTR study are to: 1) evaluate the toxicity and pharmacokinetic properties of TN-NAC in mice, and 2) test the therapeutic efficacy of TN-NAC in a 3xTG-AD mouse model of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $499,883 to Degrome Therapeutics, Inc. to develop small-molecule degraders of the amyloid precursor protein (APP) as novel therapeutics for Alzheimer's disease (AD). The project aims to optimize lead APP degrader compounds to improve their potency, solubility, and blood-brain barrier permeability, with the goal of identifying the most promising candidates for further development and evaluation...
- This Project Grant award of $475,014.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to develop a novel neurotrophic therapeutic for treating the cognitive deficits associated with Alzheimer's disease. The key products and services to be delivered through this grant include: Scaling up the production of a recombinant, non-erythropoietic neurotrophic protein that has demonstrated cognitive enhancement effects in Alzheimer's disease models. Evaluating the toxicity...
- This Project Grant award of $576,664 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Janusq LLC is funding research to evaluate the pharmacokinetics and in vivo efficacy of a macrocyclic peptide therapy (DA45) for treating mitochondrial dysfunction in Alzheimer's disease. The two-year project will assess the peptide's exposure, stability, and therapeutic effects in a mouse model of Alzheimer's, using advanced analytical methods to quantify DA45 levels in plasma and brain...
- This $500,000 Project Grant was awarded on September 15, 2024 by the National Institute on Aging (CFDA 93.866 Aging Research program) to Neucyte Inc., a minority-owned small business specializing in advanced biomedical research and development. The funding will support the development of a miniaturized "mini-brain" microphysiological system (MPS) platform using Alzheimer's disease (AD) patient-derived cells. The goal is to create a scalable, reproducible in vitro brain model that can...
This $8.13 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports clinical development activities for PTI-125, an investigational Alzheimer's disease therapeutic under development by Cassava Sciences, Inc. The funding will enable Cassava Sciences to conduct a food effect study to determine the impact of food on PTI-125 absorption, as required by the U.S. Food and Drug Administration. Additionally, the company will scale up manufacturing and analytical methods for PTI-125 oral tablets to Phase 3 commercial standards and manufacture drug supply to initiate a large Phase 2/3 clinical trial. Cassava Sciences will also select clinical trial sites, patient recruitment methods, and an electronic clinical outcome assessment platform with this funding support. The award advances the National Institute on Aging's Aging Research program objective to encourage biomedical research directed toward greater understanding and treatment of aging-related diseases.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 5/19/22 | ||
| Not listed | $0 | 5/19/22 | ||
| Not listed | $2.7m | 5/10/21 | ||
| Not listed | $2.7m | 5/10/21 |