Project Grant R44AG085775

Award Date 9/30/24
Completion Date 8/31/25
Dollars Obligated $2.4M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
San Diego, CA 92121, USA
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This $2,432,649 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports Virogenics, Inc., a biotechnology company in San Diego, California, in advancing the development of CMS121, a novel small molecule drug candidate for treating Alzheimer's disease.

The key products or services to be delivered under this grant include:

  1. Conducting 13-week toxicology studies in rats and dogs to enable longer-term clinical testing of CMS121 in human subjects with mild to moderate Alzheimer's disease.
  2. Developing a tablet formulation of CMS121 to replace the use of capsules for upcoming clinical trials.

These activities are critical steps to progress CMS121, which has shown promise in preclinical models for preventing and reversing cognitive impairments associated with Alzheimer's, towards a Phase 2 clinical trial. The grant will fund this preparatory work over the award period from September 2024 to August 2025.

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