Project Grant R01AA032723
- This federal Project Grant award was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to the University of California, San Diego (UCSD) in the amount of $248,981.00. The award will fund research to characterize the gut microbiota of patients with autobrewery syndrome (ABS) and identify microbes responsible for high levels of ethanol production, as well as examine how pathologic gut microbial ethanol production may impact...
- This $634,829 Project Grant award from the Department of Health and Human Services National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) supports a research project titled "Geroprotective Precision Medicine Strategies in PWH that Use Alcohol". The project aims to identify personalized approaches to overcoming inconsistent responses to microbiota-targeted interventions and validate their capacity to offset mechanisms of biological aging in people with...
- The Project Grant award of $131,654 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) is funding the development of a Lactobacillus-vectored alkaline phosphatase (AP) to mitigate alcohol-induced leaky gut and lipopolysaccharide (LPS) endotoxin load in the gut. The project aims to apply a two-pronged approach using: 1) Lactobacillus-based drug delivery technology to prevent alcohol-induced gut leakiness, and 2) the delivery of...
- This federal Project Grant award of $3,182,397.00 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to the University of California, San Diego (UCSD). The grant aims to characterize the role of host gut proteases, particularly cathepsin B, and the immune response in alcohol-associated liver disease (ALD) in both a human cohort and a mouse model. The research seeks to determine how alcohol-mediated induction of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $601,129 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the Cleveland Clinic Lerner College of Medicine of Case Western Reserve University (CCLCM). The project, titled "Alcohol and Gut-Brain Axis and the Role of Butyrate on Neuroinflammation and Pain Sensitivity", aims to investigate the relationship between alcohol use disorder, chronic pain, and the gut microbiome, with a focus on the role of...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $550,417 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Texas at Austin. The grant, effective September 1, 2025 through May 31, 2030, supports research to investigate how heavy alcohol exposure in aging individuals leads to impaired microglia function, neurodegeneration, and cognitive deficits. The study aims to determine whether dysregulated neuroimmune and microglia responses are...
- This Project Grant award of $123,045.00 from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) supports research on the role of the TRAF3IP2 protein in the development of alcohol-related cardiomyopathy. The project will investigate whether alcohol-induced cardiac fibroblast activation, proinflammatory cytokine expression, and extracellular matrix changes are dependent on TRAF3IP2, and whether deleting the TRAF3IP2 gene prevents alcohol-induced...
- This federal Project Grant award of $701,051 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273). The grant supports research to investigate the phenotypes and functions of distinct neutrophil populations in patients with severe alcohol-associated hepatitis (AH). Key objectives include: 1) Characterizing the transcriptomic profiles and functional roles of neutrophil subsets in AH using single-cell RNA sequencing; 2)...
- This Project Grant award of $639,177.00 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, will support research to investigate the role of hepatic FOXA3 in the development and progression of alcohol-associated liver disease (ALD). The University of Arizona will conduct this research project to gain a better understanding of the mechanisms underlying the pathogenesis of ALD, which is the most prevalent...
- The National Institute on Alcohol Abuse and Alcoholism (NIAAA) awarded a $404,250 Project Grant under the Alcohol Research Programs (CFDA 93.273) to the University of Tennessee Health Science Center. The grant, awarded on September 23, 2025 with an ultimate completion date of August 31, 2027, supports research to explore the role of margaric acid in alcohol-associated liver diseases (AALD). The project aims to determine if margaric acid supplementation can attenuate alcohol-induced gut and liver...
This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under CFDA 93.273 - Alcohol Research Programs provides $603,499.00 to the University of Texas Health Science Center at Houston (UTHealth) to develop a comprehensive, web-based knowledge module that integrates microbiota, metabolite, and host pathway data to map microbial signatures and mechanisms involved in alcohol-related organ damage (AROD). The project aims to define "alcohol enterotypes" associated with AROD and validate the platform's performance through a population-based study. The research seeks to provide insights into the role of gut dysbiosis in alcohol-induced organ damage and identify biomarkers to inform risk assessment and personalized interventions targeting the microbiome. The award period is from September 15, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $603.5k | 9/2/25 |