Project Grant R01AA031702
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $431,918 in funding to Bryant University for a research project focused on understanding the neural circuitry mechanisms underlying maladaptive reward memories related to alcohol addiction. The research aims to use the genetic tractability of the Drosophila melanogaster model organism to investigate how alcohol disrupts memory circuit activity and drives...
- This federal Project Grant award for $700,000.00, issued by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training program, supports research to investigate the neurophysiological and genetic factors contributing to binge drinking and alcohol use disorder. The primary awardee, the University of New Mexico (UNM) Health Sciences Center, will leverage techniques such as monosynaptic circuit labeling, optogenetics, electrophysiology,...
- This federal Project Grant award of $396,643 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) supports research to elucidate the mechanisms underlying stress-potentiated ethanol drinking. The project aims to investigate the role of the histone methyltransferase G9a and its effects on dynorphin-positive neurons in the nucleus accumbens to regulate this behavior. Key objectives include testing the hypothesis that G9a's effects on...
- This federal Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), will support research on the role of somatostatin in the central amygdala in relation to heavy alcohol drinking. The research team at Boston University Medical Campus will use an animal model of heavy alcohol drinking, combined with pharmacological, molecular, and electrophysiological approaches, to test the hypothesis that activation of...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- This Project Grant award, valued at $2,250,249.00 and funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports a research project conducted by the University of California, San Diego (UCSD) to investigate brain features associated with alcohol use disorder (AUD). The project aims to employ longitudinal multi-parametric magnetic resonance imaging (MRI) to assess baseline brain characteristics and changes following alcohol...
- This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (CFDA 93.273 - Alcohol Research Programs) provides $248,959 to The Medical College of Wisconsin, Inc. to conduct research on the reciprocal relationship between alcohol use and brain function in adolescents and young adults. The 5-year project aims to assess how neurocognitive mechanisms of decision-making and risk-taking in adolescence contribute to alcohol use initiation, escalation, and maintenance,...
- This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the effects of chronic intermittent alcohol exposure on orbitofrontal cortex (OFC) astrocyte physiology, structure, and gene expression, and how these changes contribute to altered OFC neuron excitability and excessive drinking behaviors. The $459,707 award, with a period of performance from September 5,...
- This Project Grant award, totaling $560,108.00 and spanning September 15, 2025 to August 31, 2030, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The purpose of the project is to investigate the neurocognitive mechanisms that promote resilience to alcohol use disorder (AUD) in individuals with a family history of AUD. Specifically, the research will examine how attentional abilities may...
- This Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA, CFDA 93.273 Alcohol Research Programs) provides $647,330 to Wake Forest University Health Sciences to conduct research on the role of epigenetics in predisposing the brain to risky alcohol use. The researchers will perform a longitudinal genome-wide DNA methylation analysis of the rhesus macaque dorsolateral prefrontal cortex to identify biomarkers associated with future alcohol drinking levels. The goal...
This federal Project Grant award of $2,150,570 was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) to Brown University. The funding supports research to investigate the circuit and molecular mechanisms through which alcohol influences natural reward systems in the brain. Specifically, the project aims to use the reduced numerical complexity of the Drosophila (fruit fly) reward/dopaminergic system as a model to study cellular resolution mechanisms of reward memory and reward-seeking behavior. The research will focus on understanding how absolute and relative sugar rewards are encoded in dopaminergic memory circuits, and the mechanisms by which alcohol is weighted relative to sugar and how prior alcohol experience alters sugar reward processing. This work is intended to reveal how relative reward value is encoded and how alcohol influences reward circuit function to elicit unconstrained reward seeking. The project period runs from September 25, 2025 through August 31, 2029.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.2m | 9/25/25 |