Project Grant R00HL177820

Award Date 5/1/25
Completion Date 4/30/28
Dollars Obligated $446K
Federal Grant Program
93.837
Assistance Type
Project Grant
Place of Performance
Massachusetts, USA
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This $5,187,690 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports a research program focused on advancing the understanding of ABO(H) blood group antigens and corresponding anti-ABO(H) antibodies. The program aims to define the factors that govern anti-ABO(H) antibody formation and the specific ABO(H) antigen targets responsible for hemolytic transfusion reactions. The research program involves three distinct projects...
This $172,800 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will support research at Brigham & Women's Hospital Inc. to investigate the role of innate immunity and blood group-positive microbes in regulating anti-ABO(H) antibody production. The key objectives are to 1) define how innate immune factors like galectins impact levels of naturally occurring anti-blood group antibodies, and 2)...
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The project aims to define the role of platelet ABO(H) blood group antigens in hemostasis and thrombosis. Specifically, the research will: 1) Investigate the impact of ABO(H) glycans on platelet binding to von Willebrand factor, and 2) Identify platelet glycoproteins that carry ABO(H) antigens using a click chemistry enrichment strategy and mass spectrometry proteomics. This work is expected to provide mechanistic insights into how platelet ABO blood type affects bleeding and clotting risk, and establish a molecular framework to facilitate future development of diagnostic tests and therapies for thromboembolic disease and hemorrhage.

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