The National Heart, Lung, and Blood Institute (NHLBI) awarded a $249,000 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to Rutgers, The State University of New Jersey, doing business as RBHS-School of Nursing. The grant, effective January 1, 2025 through December 31, 2027, will support research to quantitatively characterize lactate metabolism in the heart and test the hypothesis that myocardial lactate production and consumption is integral to cardiac health. The project aims to use isotope tracers to measure lactate fluxes in normal cardiomyocytes and hearts, define metabolic changes in the pyruvate-lactate axis during heart failure, and investigate the impact of an MCT4 inhibitor treatment on heart failure models. This research seeks to lay the groundwork for targeting lactate metabolism as a new therapeutic approach for cardiac hypertrophy and heart failure.
Generated 2/25/25, 3:18 AM