Project Grant R00HL166870
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $480,990 to the University of Illinois to investigate the role of aerocytes, a specialized capillary endothelial cell population, in guiding alveolar epithelial regeneration following lung injury. The key objectives are to determine how aerocyte-derived signaling, particularly the angiocrine factor R-spondin3, regulates alveolar...
- This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $147,486 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to The Trustees of the University of Pennsylvania, doing business as the Clinical Practices of the University of Pennsylvania. The project, titled "Identifying Inflammatory Signals Facilitating Ectopic KRT5+ Cell Migration and Their Function in the Alveoli", aims to investigate the mechanisms by which certain lung cells (KRT5+ cells)...
- This federal Project Grant award of $711,144 from the National Heart Lung and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), supports research to investigate how the architecture and glycan composition of lung mucus influences its ability to trap and neutralize diverse respiratory viruses. The primary awardee, the University of Maryland, College Park, will utilize genetically-modified airway epithelium models to determine how specific secreted mucins...
- The National Heart, Lung, and Blood Institute (NHLBI) awarded a $730,070 Project Grant under the Cardiovascular Diseases Research program (CFDA 93.837) to the University of Arizona on September 1, 2025. The goal of this research project is to develop and test a novel class of nanoparticle delivery systems that can selectively target lung capillary endothelial cells in vivo to deliver therapeutic genes like FOXM1 and stimulate lung regeneration in animal models of bronchopulmonary dysplasia (BPD)...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), provides $1,479,335 to the Massachusetts Institute of Technology (MIT) to conduct research related to Acute Respiratory Distress Syndrome (ARDS). The key objectives are to use "target trial emulation" from observational data to inform prospective ARDS research and clinical decision-making, develop advanced machine learning methods for...
- This $688,163 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research by the University of Pittsburgh to study the role of indole metabolites as danger signals in the development of acute respiratory distress syndrome (ARDS). The 4-year project aims to investigate how metabolites derived from microbes can activate regulated cell death pathways and inflammatory responses in lung epithelial cells,...
- This Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) provides $233,250.00 to the University of North Carolina at Chapel Hill to fund research on the role of lipid metabolism in lung macrophage activity and phenotypes during acute lung injury. The 2-year project, running from Sep 1, 2025 to Aug 31, 2027, will investigate how changes in lipid metabolism alter the function of lung macrophages during influenza A virus infection....
- The National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), awarded a $678,803 Project Grant to The Ohio State University to research the role of the mitochondrial deubiquitinase USP30 in regulating microvascular inflammation and acute lung injury. The research aims to determine if inhibiting USP30 in the endothelium can preserve endothelial cell function and reduce the severity of acute lung injury, potentially leading to new...
- This Project Grant award, funded by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837), aims to develop a therapeutic strategy to replace a failed component of the macrophage lung injury response and enable healing in patients with bacterial pneumonia. The $656,988 award, with a period of performance from August 1, 2025 to April 30, 2030, will be used by the Cleveland Clinic Lerner College of Medicine of Case Western Reserve...
This federal Project Grant award in the amount of $249,000 was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research grant program (CFDA 93.837). The grant supports a research plan by Dr. Zhengjie Zhou of Temple University to develop novel lung-targeting nanoparticles for delivering therapeutic mRNA to treat acute respiratory distress syndrome (ARDS), which is a leading cause of death in severe influenza and COVID-19 cases. The key proposed activities include: (1) promoting endothelial cell health through delivery of KLF2 mRNA, and (2) activating epithelial cell innate immune pathways through delivery of OAS1 mRNA. The grant project will leverage Dr. Zhou's expertise in vascular biology, lung biology, molecular biology, and bioengineering to advance this targeted mRNA therapy approach for ARDS treatment. The project period runs from August 16, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/15/25 |