This federal Project Grant award, valued at $564,445.00, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award, effective March 1, 2025 through December 31, 2031, supports the University of Texas Health Science Center at Houston's "Hypoxia-Inflammation Program" research focused on targeting hypoxia-inducible factors (HIFs) for the treatment of heart and lung diseases. The funded...
This $607,952 Project Grant award was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research at the University of Pittsburgh to investigate indole metabolites as novel danger signals that activate regulated cell death pathways in lung epithelial cells, which may contribute to the pathogenesis of acute respiratory distress syndrome (ARDS). The key research objectives include...
The federal Project Grant award of $583,233 was made by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research (CFDA 93.837) program. The grant will fund research at The Washington University in Missouri to investigate the role of circulating osteopontin and CD44 receptors on innate immune cells in driving remote lung inflammation following acute kidney injury. The key objectives are to: 1) determine which osteopontin domains and cleavage are required...
The National Heart, Lung, and Blood Institute (NHLBI) awarded a Project Grant totaling $1,147,992 to The Regents of the University of California, San Francisco (UCSF) under the Cardiovascular Diseases Research program (CFDA 93.837). The grant aims to advance precision medicine for acute respiratory distress syndrome (ARDS) and sepsis by addressing key unanswered questions about the functional immune response, biological pathways, and optimization of real-time phenotyping in these critical care...
This Project Grant award, identified as R01HL170118, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award, totaling $495,159.00, will fund research to investigate the role of the protein CARMIL1 in regulating endothelial cell barrier function and its potential impact on acute respiratory distress syndrome (ARDS). The study, to be conducted by the University of Illinois, will use...
This $1,398,770 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research Federal Grant Program (CFDA 93.837), is funding research to investigate the role of serum amyloid A (SAA) and its association with high-density lipoprotein (HDL) in mediating the resolution of sepsis-induced acute lung injury and mortality. The central hypothesis is that systemic SAA-HDL regulates neutrophil infiltration into injured lungs, thereby...
This Project Grant award, valued at $607,535, was provided by the National Heart Lung and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The grant supports research to investigate the effects of the breakdown product hemin on the pulmonary endothelium and its contribution to the pulmonary complications of sickle cell disease, including acute chest syndrome and pulmonary hypertension. The research aims to evaluate the specific effects of...
The federal Project Grant award R01HL173531, totaling $737,815, was provided by the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research federal grant program (CFDA 93.837). The award supports the development and validation of an automated electronic health record (EHR)-embedded Clinical Classifier Model (CCM) system to rapidly identify distinct molecular phenotypes of acute respiratory distress syndrome (ARDS) and sepsis at the bedside. This will enable...
This federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) at the National Institutes of Health provides $1,568,003.00 to the University of South Alabama to investigate the molecular mechanisms by which the protein progranulin regulates endothelial cell function and blood pressure control. The research aims to determine if reduced progranulin levels in endothelial cells facilitate the development and progression of...
The U.S. National Heart, Lung, and Blood Institute (NHLBI) awarded a $498,991.40 Project Grant to the University of Arkansas under the Cardiovascular Diseases Research (CFDA 93.837) federal grant program. The funding supports the development of microphysiological systems to study hypoxic cardiac injury resulting from acute myocardial infarction and ischemia-reperfusion injury. The research aims to engineer microfluidic devices to precisely control oxygen levels and investigate how oxygen...