Project Grant R00GM151473
- This federal Project Grant award of $294,060 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research to understand biophysical principles of cellular organization at two scales: bacterial communities and intracellular biomolecular condensates. The research aims to elucidate how bacterial quorum sensing operates in natural environments, including the influence of other species, and to investigate...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- This federal Project Grant award of $360,247, granted by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to investigate the mechanisms underlying the function and regulation of signaling effectors associated with type III CRISPR-Cas systems in microbes. The research aims to advance the understanding of how these RNA-guided immune systems in bacteria and archaea use cyclic nucleotide second...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will support research into the molecular mechanisms of ribosome biogenesis by force-producing enzymes. The $392,500 award to Rutgers, The State University of New Jersey will fund a 5-year project focused on characterizing how ATP-driven mechanoenzymes sequentially convert ribosomal precursors into mature ribosomes. Key activities...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
- This federal Project Grant award of $584,420 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports the "Spatiotemporal Mapping and Engineering in the Dark Proteome" research project at the Albert Einstein College of Medicine. The research aims to investigate how protein motions associated with intrinsic disorder contribute to specific biological functions, utilizing methods such as NMR,...
- This federal Project Grant award, valued at $375,430.00 and awarded on February 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports research to investigate the regulation of germ granules, a type of RNA condensate, by RNA helicases and the impact of condensation on RNA helicase activity. The research aims to establish a framework for understanding the regulation of RNA...
- This federal Project Grant award of $425,302.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research into the novel regulation of fibrinogen expression and function. The research aims to address key scientific questions about how plasma fibrinogen levels are regulated during the acute phase response, the cellular sources of fibrinogen in various inflammatory settings, and the molecular...
- This federal Project Grant award from the National Science Foundation's Biological Sciences program (CFDA 47.074) provides $776,309 to The Pennsylvania State University to conduct research on the structural responses of intrinsically disordered proteins to chemical modifications that regulate gene expression. The project aims to develop new experimental methodology for nuclear magnetic resonance (NMR) spectroscopy to gain quantitative insights into these regulatory mechanisms. The research...
- This federal Project Grant award of $390,000.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research to elucidate the mechanisms underlying DNA double-strand break repair at Thomas Jefferson University, doing business as Sidney Kimmel Medical College. The research aims to determine the regulatory mechanisms of the multi-protein and multi-step process required to coordinate the repair of DNA...
The federal Project Grant award of $249,000.00, provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to characterize protein condensates and nuclear organization in maintaining genomic integrity. The award, with a performance period from September 1, 2025 to July 31, 2028, is being provided to Rutgers, The State University of New Jersey to investigate the mechanisms by which the tumor suppressors BRCA1 and 53BP1 undergo liquid-liquid phase separation to form biomolecular condensates and how this process contributes to DNA repair pathways and chromatin organization. The research aims to advance the understanding of how disruptions in these critical maintenance systems can lead to genomic instability and disease.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/28/25 |