Project Grant R00GM149982
- This federal Project Grant award of $565,826.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports research conducted by Duke University to investigate how animals, using the C. elegans model organism, maintain developmental homeostasis and respond to fluctuations in nutrient availability. The research focuses on elucidating the role of key regulatory pathways, such as insulin/IGF signaling and...
- This federal Project Grant award of $460,740.00 was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University. The project aims to develop novel quantitative experimental and computational methods for studying continuous phenotypic transitions in cellular states, with applications across ovarian aging, cardiovascular disease, and hormone-dependent cancers. Key objectives include using...
- This $162,874 Project Grant award was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) to The Trustees of Princeton University. The goal of this research project is to quantify protein dynamics and post-transcriptional regulation within the ectoderm germ layer of Drosophila (fruit fly) embryos. The researchers will use genetically modified Drosophila embryos expressing uniform morphogens to analyze...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $387,500 Project Grant to The Johns Hopkins University on May 1, 2025. The funding supports a research program that systematically investigates the roles of conserved microRNAs during animal development. The research leverages the experimental system provided by C. elegans, utilizing state-of-the-art molecular biology and genetics approaches. The...
- This federal Project Grant award of $460,740 from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 (Biomedical Research and Research Training program) will support research by Yale University to develop scalable methods for inferring the most important interactions within large biological networks. The goal is to investigate two model systems: (i) neural activity and (ii) chromatin structure, in order to identify the networks of interactions that best describe...
- This $382,500 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research by Washington State University (WSU) into the molecular and neural mechanisms that regulate stress responses. The research focuses on how organisms deploy appropriate stress responses to counter internal and external threats, and how neural circuits can attenuate overreactive stress responses to...
- This federal Project Grant award of $669,801 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research at Yale University to study the proteomic and phosphoproteomic remodeling associated with genomic imbalances, such as in aneuploid cells. The research aims to distinguish the mechanisms of proteomic remodeling and tolerance in chromosome gain versus loss type aneuploidies, as well as to apply...
- This federal Project Grant award, valued at $372,880 and issued on May 1, 2025, is funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The grant supports a research project aimed at understanding how cells regulate protein synthesis to maintain homeostasis during cellular stress. The key focus is on investigating the role of the translation initiation factor eIF2 and its phosphorylation in modulating gene...
- This $423,500 Project Grant, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research at the University of Utah focused on understanding the molecular mechanisms of genomic conflicts and hybrid incompatibilities in Drosophila. The key products and services to be delivered include research on: 1) the molecular basis of hybrid lethality between Drosophila melanogaster and sister species, 2)...
- This Project Grant award, valued at $2,050,000.00 and funded by the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training, supports research to decipher the sexually dimorphic neural substrates governing aggression in female Drosophila melanogaster (fruit flies). The research aims to elucidate the neural mechanisms encoding sex-specific primal behaviors, investigate the modulatory effects of stress and peptides on female aggression,...
The National Institute of General Medical Sciences (NIGMS) awarded a $248,975 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to Yale University on August 28, 2025. The project, titled "Stress Response Signaling as a Metabolic Sensor in Reproduction," aims to examine how nutrient sensing alters reproductive capacity via the integrated stress response (ISR) signaling pathway and steroid hormones in the Drosophila model organism. The research will uncover the mechanistic link between metabolic status and gametogenesis, as well as the regulation of egg-laying behavior by the ISR. During the award period, the project will utilize a novel neural editing tool to characterize the role of ISR signaling in post-mating changes in intestinal function and courtship behavior. The project is scheduled for completion by July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/27/25 |