This federal Project Grant award from the National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training Program) provides $427,625 to the University of Maryland, Baltimore to study the conformational dynamics and regulatory mechanisms of the KCNH family of ion channels. The research aims to investigate the voltage sensor domain, S4 helix, and intracellular regulatory domains of these channels to elucidate the fundamental mechanisms of voltage-dependent...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) will support research to investigate the mechanical regulation of protein kinase A (PKA) function in cell adhesion and migration. The $294,974 award, effective August 1, 2024 through May 31, 2029, will allow researchers at the University of Vermont to use biophysical, biochemical, and cell biological approaches to characterize how...
This federal Project Grant award, valued at $733,870.00 and effective from September 1, 2024 to August 31, 2029, was provided by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The objective of this award is to advance the fundamental understanding of cell signaling through quantitative analysis of membrane protein interactions, with a focus on receptor tyrosine kinases (RTKs) and G protein-coupled receptors...
This National Science Foundation Project Grant under the Integrative Activities program (CFDA 47.083) provides $193,620 to the University of Delaware from February 1, 2023 to January 31, 2025. The funding will support research using computational and experimental ultrafast vibrational spectroscopy to unravel the gating mechanisms of ion channels. Specifically, the awardee will combine molecular dynamics simulations with computational spectroscopy to study activation mechanisms of potassium...
This federal Project Grant award of $118,904, funded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), aims to deconvolute the complex mechanisms of signal transduction in bacterial histidine kinases through protein design and engineering. The principal investigator proposes to use a protein design approach to generate tunable versions of signaling subdomains and incorporate them into wild-type histidine...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $387,500.00 to The Johns Hopkins University to conduct research on the molecular mechanisms that regulate the activity of protein kinases. The research program will use the Hippo signaling pathway as a model system to investigate different mechanisms that modulate the activity of protein kinases, which play a critical role...
This is a $385,191 Project Grant awarded by the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) to The Trustees of Trinity College, a private non-profit university in Hartford, Connecticut. The grant will fund research to study the structure, function, and energetics of ATP-sensitive potassium (KATP) channels, which play a critical role in coupling cellular metabolism to electrical activity in pancreatic beta cells and the...
This $584,420 federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports spatiotemporal mapping and engineering research on the "dark proteome" - intrinsically disordered proteins and their functions. The award, which runs from April 1, 2025 to January 31, 2030, enables researchers at the Albert Einstein College of Medicine to investigate the role of protein disorder in nuclear...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $401,242 to support research aimed at improving drug development through studies of protein kinase inhibitors. The main goals of the program are to evaluate aspects of drug development, offer new methods to reduce the guesswork and accelerate the delivery of new therapies, and fill gaps in knowledge related to drug...
This $725,000 five-year Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) supports research to investigate the impact of redox (oxidation-reduction) regulation on protein kinase function and cellular signaling. The research program, led by North Carolina Agricultural and Technical State University (NC A&T), aims to examine how reversible oxidation of protein kinases affects their substrate...