Project Grant R00GM144750
- This federal Project Grant award of $2,203,340.00, awarded on September 20, 2025 by the National Institute of General Medical Sciences (NIGMS), is part of the Biomedical Research and Research Training program (CFDA 93.859). The grant supports fundamental research to define the mechanistic rules governing how transcription factors (TFs) bind to chromosomal DNA within compacted chromatin. The goal is to systematically dissect the factors required for initial and sustained TF binding to...
- This Project Grant award of $568,113 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) supports research into variant chromatin structures and their functions. The research aims to investigate how these specialized chromatin particles, including the histone variant H2A.Z, are targeted to specific genomic sites and how they modulate transcription. The project will leverage a novel in vitro transcription...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA 93.859 Biomedical Research and Research Training Program provides $144,362.00 to The Research Foundation For The State University Of New York to investigate the mechanism of Ess1-mediated regulation of the CTD of RNAP II phase separation. The project will be conducted at the Upstate Medical Center in Syracuse, NY and is expected to be completed by April 30, 2025. This research aims to...
- The federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under CFDA program 93.859 - Biomedical Research and Research Training is supporting a $3,125,817 research project at New York University School of Medicine titled "Decoding Positional Epigenetic Memory." The project aims to decipher how stable positional identity is generated through the regulation of HOX gene expression, which is crucial for proper cell differentiation and disease...
- This federal Project Grant award of $156,980 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project titled "Mechanisms of SAGA Regulation by Histone Crosstalk". The project aims to study the acetylation activity of the SAGA transcriptional co-activator complex on mono- and di-nucleosomes with biologically relevant post-translational modifications. This research will...
- This federal Project Grant award of $436,001 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), aims to create a novel spatial transcriptomics platform that increases accessibility and efficiency. The key products and services to be delivered include: Developing a spatial transcriptomics platform using a simple filter array format that increases sequencing depth per spatial barcode, enabling more data per...
- The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $431,656 Project Grant to the University of Massachusetts to elucidate the function of ribonucleoprotein (RNP) condensates in living cells. The research aims to develop novel methods to accurately identify the RNA-binding proteins that regulate the formation and disassembly of RNP condensates, which play a crucial role in cellular function and disease...
- The National Institute of General Medical Sciences (NIGMS) awarded a $377,123 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RF SUNY) on September 1, 2025. The grant supports a research program aimed at providing structural and mechanistic insights into the ligand specificity of A1-adrenergic receptors (A1-ARs) through the use of cryo-electron microscopy, biochemical, and cellular studies....
- The National Institute of General Medical Sciences (NIGMS) awarded a $492,000 Project Grant with the CFDA program title "Biomedical Research and Research Training" to St. John's University, New York. The grant supports a 3-year research project investigating how the checkpoint kinases Mec1p and Rad53p regulate transcription termination, particularly the role of these kinases in pre-mRNA 3' end processing and the NRD1-NAB3-SEN1 (NNS) termination pathway. The research aims to elucidate...
- This federal Project Grant award of $534,160.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research program to investigate the molecular mechanisms underlying proteins and protein complexes that facilitate intracellular ion transport and ensure genomic integrity. The research aims to elucidate the mechanisms by which ions are recognized and transported across membranes, how the...
The National Institute of General Medical Sciences (NIGMS) awarded a $249,000 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Research Foundation for the State University of New York (RFSUNY), doing business as Stony Brook University. The grant will fund a 3-year research project from September 1, 2025 to August 31, 2028 to study the "Dynamic Mechanisms of Transcriptional Coactivator Function in Notch Signaling." The research aims to identify co-activators that interact with the MAML1 protein and determine how they work with the Notch transcription complex to induce gene expression. It will also visualize MAML1 nuclear dynamics and assess the role of higher order protein assemblies in Notch-dependent transcription. This research seeks to address fundamental questions about transcription factor function and activity, with the Notch signaling pathway as a model system.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 8/27/25 |