This federal Project Grant award, with an ID of R01AG081520, was issued by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The award provides $684,924 in funding to Northwestern University to conduct a 5-year research project investigating the relationship between noradrenergic dysregulation, sleep quality, and cognitive function in older adults with insomnia. The key objectives of the project are to systematically characterize central and peripheral...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,498,158 to develop a testable prototype for a novel closed-loop feedback neuromodulation system to improve slow wave sleep in Alzheimer's disease patients. The device is intended to promote healthy sleep onset, duration, and sleep stage architecture, including slow wave sleep, to prevent the disease-accelerating impacts of disrupted sleep on Alzheimer's disease progression. The awardee,...
This $442,938 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will fund research to elucidate changes in sleep, memory, and synaptic plasticity that occur with aging, and identify mechanisms to prevent or reverse age-related memory decline. The primary awardee, The Regents of the University of California, San Francisco (UCSF), will conduct a series of studies in the C. elegans model system to: Characterize how aging affects the sleep patterns...
This $1,001,704 Cooperative Agreement award from the National Institute on Aging (NIA, CFDA 93.866 Aging Research) will support a multi-year project to validate methods for analyzing NAD and its metabolites in human clinical studies. The project aims to: Develop and standardize analytical methods for measuring NAD, NADH, NADP, and NADPH in blood-derived samples, including through liquid chromatography-mass spectrometry, biochemical assays, and nuclear magnetic resonance. Conduct a clinical trial...
This $258,498 Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), supports research to investigate the biological pathways linking sleep health to Alzheimer's disease and cognitive decline. The key objectives are to: Use a multi-omics approach to analyze methylation and metabolomics data associated with short sleep and insomnia among a high-risk Hispanic population, and compare the results to Alzheimer's disease biomarkers to identify...
The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
This $537,000 project grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Brigham & Women's Hospital Inc. aims to culturally adapt and pilot a social network-based approach to deliver a sleep health and mindfulness program to cognitively unimpaired older adults living in low-income housing in Boston. The project will involve iterative feedback and prototyping to ensure the adapted sleep and mindfulness program is accessible and feasible for the target...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $191,700 to Northwestern University to investigate the relationships between sleep disturbance, cognitive function, and health status among middle-aged adults. The principal investigator, Dr. Minjee Kim, aims to: 1) examine associations between sleep disturbance, cognitive function, self-care capacity, and overall health; 2) develop predictive models for sleep disturbance using...
This $1,955,041 Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research into the relationship between sleep, pericytes, and Alzheimer's disease pathology. The Medical University of South Carolina will investigate whether pericytes, cells that regulate cerebral blood flow and blood-brain barrier permeability, mediate the effects of sleep disruption on Alzheimer's disease progression. Specifically, the...
This $7.72 million project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The Seattle Institute for Biomedical and Clinical Research will define the role of post-traumatic brain injury sleep disruption and glymphatic dysfunction in the development of Alzheimer's disease and chronic traumatic encephalopathy neuropathology. Over three years, the grantee and three sub-awardees will...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) totaling $790,101.20 will assess the potential benefits of nicotinamide riboside (NR) supplementation on sleep quality, objective sleep duration, and cognitive function in older adults. The award recipient, The Research Foundation for the State University of New York (RF SUNY), will build upon a previous VA-funded clinical trial to examine how NR, a form of vitamin B3, may improve mitochondrial function and increase expression of brain-derived neurotrophic factor (BDNF) to support healthy sleep and cognition in the aging population. This 1-year project will evaluate sleep parameters and cognitive outcomes in older adults receiving a 3-month NR or placebo intervention, with the goal of confirming NR as a low-risk, low-cost approach to promoting healthy aging through improved sleep and cognitive function.