Project Grant R00AA030031
- This $825,383 federal Project Grant award was provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), to the University of Massachusetts Medical School (UMMS) located in Worcester, MA. The grant supports research to investigate the relationship between disruptions in molecular rhythms in specific cell types of the striatum and opioid use disorder (OUD) using human postmortem brain samples and mouse models. The project aims to...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), provides $399,739 to Attune Neurosciences, Inc. to develop a head-worn low-intensity focused ultrasound (LIFU) device for enhancing sleep in individuals with substance use disorder (SUD), including opioid use disorder (OUD). The project aims to reconfigure Attune's existing LIFU technology into a more wearable, user-friendly device, and conduct a...
- The University of Pittsburgh is the recipient of a $440,543 federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273). This award, titled "ROLE OF CELL TYPE-SPECIFIC MOLECULAR RHYTHM DISRUPTION IN ALCOHOL USE DISORDER," will be used to investigate how molecular circadian rhythms are altered in specific cell types within the nucleus accumbens of the human brain in individuals with alcohol use...
- This $476,123 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to understand the genetic and molecular connections between substance use disorders, including opioid use disorder, and circadian function. The research team at Carnegie Mellon University will leverage machine learning and genomic technologies to investigate how genetic variants impact the circadian regulation of gene...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $931,338 to Virginia Commonwealth University (VCU) to conduct a mechanistic study on the role of the orexin system and insomnia within a buprenorphine opioid use disorder (OUD) treatment sample. The study aims to investigate how the orexin system and insomnia engage neurobiological mechanisms in individuals with OUD, with the goal of identifying...
- This Project Grant award was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA), which falls under the federal Alcohol Research Programs (CFDA 93.273). The $692,723 award will support a double-blind, placebo-controlled clinical trial to test whether the drug suvorexant can be used as a novel therapeutic for alcohol use disorder (AUD) and stress-related drinking. The 5-year project, running from September 2025 through August 2030, will be conducted by researchers at The...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- This $249,860 Project Grant award from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) will support research to delineate the function and brain circuitry involving a specialized subtype of dual serotonergic-glutamatergic neuron, with the goal of understanding its potential role in linking sleep architecture, substance use disorder, and major affective disorders. The research will be conducted by President and Fellows of Harvard College, doing...
- This federal Project Grant award for $395,995.00 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant will fund a 5-year prospective study to investigate the bidirectional relationship between cannabis use, sleep, and the hypothalamic-pituitary-adrenal (HPA) axis in 60 participants aged 21-29 years, including healthy controls, moderate cannabis users, and those...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $903,965 to the University of Alabama at Birmingham (UAB) to conduct research on prefrontal circuits controlling heroin seeking behavior. The project aims to identify two functionally opposing prefrontal subcircuits that drive versus limit opioid seeking, with a focus on understanding the role of the infralimbic prefrontal cortex...
The Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273), is providing $248,990 to the University of Alabama at Birmingham to determine whether dopaminergic dysfunction underlies sleep and circadian disruptions in opioid use disorder (OUD), and whether bright light therapy can reduce these disturbances, normalize dopaminergic transmission, and improve treatment outcomes in OUD patients. The project aims to use a multi-method approach including actigraphy, polysomnography, salivary melatonin, questionnaires, and PET scans to assess sleep, circadian rhythms, and striatal D1R and D2R availability. A randomized, placebo-controlled trial will also be conducted to evaluate the effect of home-based bright light therapy on OUD recovery. The award period spans from September 16, 2025 to August 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 9/16/25 |