This federal Project Grant award, totaling $517,248.00, was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program. The award supports research to explore the mechanisms by which acute and chronic alcohol exposure regulate a norepinephrine-astrocyte-dopamine arousal pathway in the ventral periaqueductal gray (VPAG) region of the brain, and how this pathway contributes to alcohol-related changes in sleep behavior....
This $711,808 Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) will support a multi-year research project at Yale University to investigate the neural mechanisms underlying the stress response and its relationship to chronic alcohol consumption. The key objectives of the research are to: 1) develop a connectome-based model to predict stress responses using functional MRI data, 2) characterize dynamic...
This federal Project Grant award, provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) grant program, supports a clinical neuroscience study to understand the relationship between chronic stress and alcohol use disorder (AUD). The total funding amount is $275,171.12, with an award date of July 24, 2024 and an ultimate completion date of June 30, 2024. The study aims to objectively assess chronic stress and examine dynamic...
This $156,204 Project Grant award, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), supports research to investigate the role of BNST PKCdelta neurons in compulsive ethanol intake behaviors. The research aims to: 1) Evaluate adaptations in BNST PKCdelta neuron calcium transients across an abstinence period during operant behavior; 2) Dissect population dynamics in BNST PKCdelta calcium transients in response to ethanol...
This federal Project Grant award of $581,869 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the CFDA 93.273 Alcohol Research Programs, will fund a human neuroscience study to investigate the role of glucocorticoid receptor (GR) antagonism in alcohol use disorder (AUD). The study will evaluate the effects of a selective GR antagonist, PT150, on behavioral, neuroendocrinological, and physiological responses to stress and alcohol in 34 participants. The research aims...
This federal Project Grant award from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) program, provides $499,442 in funding to The Regents of the University of California, San Francisco (UCSF) from August 20, 2024 through July 31, 2027. The award supports research to investigate the role of brain-derived neurotrophic factor (BDNF) signaling in the ventral hippocampus and its contribution to the acute anxiolytic and social...
This Project Grant award, valued at $206,021, was provided by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) federal grant program. The award will support a mentored research study led by Dr. Matison McCool at the University of New Mexico's Center on Alcohol, Substance Use, and Addictions (CASAA). The study aims to develop Dr. McCool's expertise in mindfulness-based interventions, heart rate variability (HRV), advanced...
The federal Project Grant award R01AA031609, funded by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273), is providing $407,060 to The Johns Hopkins University to conduct research on the neural circuit effects of chronic alcohol exposure. The key objectives are to: Characterize changes in neural activity within the anterior cingulate cortex, orbitofrontal cortex, and dorsomedial striatum of rats exposed to chronic alcohol, as they...
This federal Project Grant award, valued at $356,037.00, was issued by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) under the Alcohol Research Programs (CFDA 93.273) on August 1, 2024. The award will fund research at Columbia University's Health Sciences Division to investigate the cellular and neuromodulatory mechanisms underlying attention control and information gathering processes. Specifically, the research aims to: 1) provide behavioral evidence for the hypothesis that...
This Project Grant award for $545,282 from the National Institute on Alcohol Abuse and Alcoholism (NIAAA), under the Alcohol Research Programs (CFDA 93.273) federal grant program, aims to investigate neural mechanisms associated with cognitive reappraisal and alcohol cue reactivity in individuals with alcohol use disorder (AUD) during early abstinence. The key objectives are to: 1) determine how neural mechanisms related to reappraisal and alcohol cue-reactivity change across early abstinence...