This $3,262,895 Project Grant awarded by the National Institute of Mental Health (NIMH) under the Mental Health Research Grants (CFDA 93.242) program supports research by Northwestern University to understand how gene expression and small GTPase signaling pathways within specific neuronal subtypes regulate the assembly and function of cortical neural circuits that enable complex behaviors and decision-making. The research aims to mechanistically connect the regulation of GTPase signaling to the hierarchical organization of brain circuits underlying mental health disorders. This 5-year award includes a sub-award to the University of Florida to study the control of synaptic circuits by small GTPase pathways. The project leverages Northwestern's expertise in multi-level biological research spanning molecular, cellular, circuit, and behavioral domains to advance fundamental understanding of the neural mechanisms underlying cognitive processing and adaptations.
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