Project Grant P41EB035084

Award Date 5/16/25
Completion Date 4/30/30
Dollars Obligated $1.3M
Federal Grant Program
93.286
Assistance Type
Project Grant
Place of Performance
Michigan, USA
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This Project Grant award for $499,291 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) will develop breakthrough technology to enable future compact, mid-field (0.7 Tesla) magnetic resonance imaging (MRI) systems. The goal is to make high-quality MRI technology more accessible globally, particularly in remote and resource-limited settings, by reducing...
This $536,954 Project Grant awarded by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" (CFDA 93.286) program supports the development of an ultra-high spatial resolution photon-counting computed tomography (CT) system with multiple focal spots. The key objectives are to: Develop system models and reconstruction approaches for data acquisition using multiple focal...
The National Institute of Biomedical Imaging and Bioengineering (NIBIB) awarded a $1,295,800 Project Grant under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286) to The General Hospital Corporation, doing business as Massachusetts General Hospital (MGH). The grant funding is to develop a novel non-rotating nano-optic endoscope for 360-degree in vivo imaging capabilities for diagnostic applications in the cardiovascular, pulmonary, and...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the "Discovery and Applied Research for Technological Innovations to Improve Human Health" program (CFDA 93.286) will support the Michigan Translational Imaging Program (M-TIP) at the University of Michigan. The $184,010 award will enable M-TIP to train a new generation of interdisciplinary translational imaging scientists over a 5-year period from May 2025 to April 2030. The...
This federal Project Grant award, provided by the National Cancer Institute (NCI) under the Cancer Detection and Diagnosis Research program (CFDA 93.394), supports the development of a real-time functional imaging platform to detect and characterize prostate cancer aggressiveness. The $568,151 award, effective from February 3, 2025 to January 31, 2030, will enable the Regents of the University of Michigan to: Optimize biocompatible polyacrylamide hydrogel nanoscale probes (PAA NPs) for...
This Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the federal Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $640,232 to the University of California, Irvine to develop a new nonlinear digital microscopic holography platform. The objective is to create a transformational imaging tool capable of high-speed 3D chemical mapping with submicron resolution, enabling deeper...
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This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $560,770 to the University of Arizona to develop and evaluate 3D-printed glass micro-optical systems for biomedical and clinical imaging applications. The key objectives are to build a custom 3D printing system with a large field of view to enable...
The University of Arizona was awarded a $1,337,953.41 Project Grant by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286). The funding will support the development and dissemination of an advanced 2-photon Bessel beam light sheet (2PBLS) microscopy instrument for high-speed, sub-micron resolution volumetric imaging in deep tissue. The proposed instrument...
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This Project Grant award of $1,302,368 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) under the Discovery and Applied Research for Technological Innovations to Improve Human Health (CFDA 93.286) program will establish a National Center for Biomedical Imaging and Bioengineering at the University of Michigan. The key products and services to be delivered include:

  1. Development of miniature scanners, actuators, and sensors for fiber-coupled microendoscopes to improve imaging capabilities such as field-of-view, signal-to-noise ratio, contrast, frame rate, and temporal resolution.

  2. Creation of advanced fiber-coupled microendoscopes using single-axis confocal, multiphoton, and dual-axes confocal photoacoustic imaging modalities for live in vivo imaging.

  3. Development of software for image registration, processing, and machine learning models for automated digital pathology, as well as protocols for correlative live and postmortem imaging with molecular analysis.

The center aims to serve as a national resource for microsystems-based imaging technologies and provide training on these advanced imaging techniques for both junior and outside investigators. The award period runs from May 2025 through April 2030.

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