Project Grant P30AG086403

Award Date 6/1/25
Completion Date 3/31/30
Dollars Obligated $5M
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Nashville, TN 37203, USA
Similar Awards
The National Institute on Aging (NIA), under the Aging Research (CFDA 93.866) Federal Grant Program, awarded a $2,552,654.85 Project Grant to Vanderbilt University Medical Center. The grant, awarded on January 1, 2025, will fund a 5-year project to systematically screen and validate drug repurposing candidates for Alzheimer's disease and related dementias (AD/ADRD). The key products and services to be delivered include: Integrating genetics, transcriptomics, literature, and clinical data to...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $1,820,685.15 to Vanderbilt University Medical Center to systematically screen and validate drug repurposing candidates for Alzheimer's disease and related dementias (AD/ADRD). The project aims to integrate genetics, transcriptomics, literature, and clinical data to develop and share tools that can systematically screen, prioritize, and validate drug repurposing candidates and their combinations...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $3,946,385.00 to Vanderbilt University to develop novel analytic approaches to dissect cell-cell communication among microglia, astrocytes, and neurons, and understand how these communications are dysregulated during Alzheimer's disease (AD) progression. The project aims to: 1) develop network-based models and statistical methods to identify cell-cell communications linked to AD pathogenesis, 2)...
The National Institute on Aging (NIA) awarded a $972,000 Project Grant under the Aging Research (CFDA 93.866) program to Vanderbilt University Medical Center (VUMC). The grant, which runs from August 2024 to May 2029, will support research to characterize the genetic architecture underlying the age of onset of amyloid positivity in Alzheimer's disease. The project will leverage advanced imaging and AI techniques to analyze amyloid PET data from over 16,000 participants, with the goal of...
This federal Project Grant award from the National Institute on Aging (NIA), under CFDA 93.866 Aging Research, provides $787,103 to Vanderbilt University to develop a novel siRNA-lipid conjugate technology called "siRNA-EG18" for targeted gene silencing in brain myeloid cells as a potential treatment for Alzheimer's disease. The project aims to comprehensively analyze siRNA-EG18's ability to silence key Alzheimer's-related genes like CD33 in myeloid cells, including under aging and...
This $481,250 Project Grant was awarded by the National Institute on Aging (CFDA 93.866 Aging Research) to Vanderbilt University Medical Center (VUMC) on September 1, 2024. The award supports the development of an innovative, non-invasive MRI imaging technique to assess membrane lipid properties in Alzheimer's disease (AD). The key objectives are to: 1) verify the relationship between the MRI nuclear Overhauser enhancement (NOE) signal and lipid properties using reconstituted phospholipid...
The National Institute on Aging (NIA) awarded a $4,663,946 Project Grant (CFDA 93.866 - Aging Research) to The University of Texas Southwestern Medical Center (UT Southwestern) to establish the North Texas Alzheimer's Disease Research Center (NT-ADRC). The NT-ADRC will conduct innovative research, training, and outreach on the role of hypertension and other cardiometabolic factors in the early stages of Alzheimer's disease and related dementias. Key focus areas include developing novel...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $185,012 to Vanderbilt University Medical Center to examine the influence of sociodemographic and medical factors on the performance of the plasma biomarker p-tau217 for early detection of Alzheimer's disease in diverse populations. The key products and services to be delivered include: 1) Quantifying the impact of factors like obesity and kidney disease on p-tau217 levels in a cohort of 3,500...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to create an inter-Alzheimer's Disease Research Center (ADRC) set of objectively measured cerebral small vessel disease (SVD) magnetic resonance imaging (MRI) biomarkers from large and diverse clinical cohorts. The $790,491 award will fund the development and validation of novel deep-learning methods to accurately quantify SVD biomarkers, including cerebral microbleeds, white matter...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $125,373 to The Trustees of Columbia University in the City of New York to conduct research on the genetic association between Alzheimer's disease and cardio-cerebrovascular risk factors. The key objectives are to 1) identify genes that interact with cardiovascular and cerebrovascular risk factors to confer Alzheimer's disease risk, and 2) identify epigenomic and transcriptomic...

This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $5,048,928 to establish the Vanderbilt Alzheimer's Disease Research Center (VADRC) in Nashville, Tennessee. The VADRC aims to characterize the intersection between vascular risk factors and Alzheimer's disease and related dementias (ADRD) pathogenesis, manifestation, prevention, and treatment. Key activities include:

  • Establishing an administrative core to coordinate local ADRD research activities and collaborations
  • Building an outreach, recruitment, and engagement core to raise ADRD awareness in the community and recruit 400 participants with vascular risk profiles into the clinical core
  • Deploying a clinical core to deeply phenotype and annually follow the 400 participants, capturing clinical, neuropsychological, cardiac imaging, neuroimaging, and biofluid data
  • Obtaining post-mortem brains and biofluids through a neuropathology core for complete characterization of ADRD and vascular pathologies
  • Developing an integrated data management and statistical core to properly store, share, and provide access to the research data

The award period runs from June 1, 2025 to March 31, 2030, supporting this comprehensive effort to better understand and address the complex relationship between vascular risk and ADRD in the Nashville region.

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