Project Grant P01AI198696
- The National Institute of Allergy and Infectious Diseases, part of the Department of Health and Human Services, awarded New York University $2.064597 million on April 15, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct pig-to-human xenotransplantation research using a decedent model. NYU Langone will perform 20 thymokidney xenotransplants in human decedents and monitor clinical, immunological, and physiological outcomes for up to 60 days post-transplant....
- The National Institute of Allergy and Infectious Diseases awarded the University of Maryland, Baltimore $777,421 on September 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to optimize immunomodulation strategies for cardiac xenograft transplantation. The recipient is conducting research to overcome rejection mechanisms in cardiac xenotransplants, building on prior work within the IXCRP Consortium that led to the world's first two human cardiac...
- The National Institute of Allergy and Infectious Diseases awarded $492,250 to Terasaki Institute for Biomedical Innovation on February 2, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop a vascularized porcine liver on-a-chip platform capable of modeling human xenoimmune responses toward porcine liver xenografts. The award supports research addressing xenogeneic rejection, coagulation dysregulation, and thrombocytopenia that currently limit porcine...
- The Department of Health and Human Services National Institutes of Health Office of the Director awarded The Trustees of Columbia University in the City of New York $814,060 on July 15, 2026, under the Research Infrastructure Programs (CFDA 93.351) to develop and provide HLA-transgenic fetal pig thymus tissue for human immune system mouse construction. The award funds development of a widely available resource of fetal thymic tissue from HLA-A2/DQ8 knock-in miniature swine to support the human...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $444,125 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2027. The award supports investigator-initiated biomedical research focused on developing and evaluating therapeutic interventions for xenotransplantation rejection. Specifically, the...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $822,280 on August 13, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research on intragraft alloreactive T cells in human solid organ transplantation, with the goal of controlling rejection after transplantation. The research dissects intragraft T cell alloimmunity using longitudinal surveillance biopsies from intestinal...
- The National Institute of Allergy and Infectious Diseases awarded $836,711 to The Trustees of Columbia University in the City of New York on May 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate whether selective matching of donor and recipient major histocompatibility complex class II molecules decreases rejection and promotes regulatory tolerance in intestinal transplantation. The research addresses high rejection rates in intestinal...
- The National Institute of Allergy and Infectious Diseases awarded the Regents of the University of Minnesota $769,846 on August 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate mechanisms governing interspecies chimeric hearts for xenotransplantation. The research develops strategies to engineer porcine embryonic hosts deficient in key developmental regulatory factors, creating a developmental niche for donor stem cells to populate and generate...
- The National Institute of Allergy and Infectious Diseases awarded Duke University $1.228 million on June 16, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to develop donor-specific transplant tolerance strategies using immune reset approaches in a rhesus monkey kidney allograft model. The research combines T regulatory cell–promoting strategies, including an IL-2 mutein (MIL-2) administered in combination with rapamycin, anti-CD154 monoclonal antibody, IL-6...
- The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $3,144,408 on February 6, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to investigate regulatory T cell memory in human tissues. The award funds research to characterize the role, identity, and function of human regulatory T cells (Tregs) across diverse tissues and their interactions with immune and structural cells. The project will...
The National Institute of Allergy and Infectious Diseases awarded The Trustees of Columbia University in the City of New York $3,040,700 on August 1, 2026, under the Allergy and Infectious Diseases Research program (CFDA 93.855) to advance xenotransplantation without immunosuppressive maintenance. The award funds two integrated research projects and three supporting cores investigating methods to achieve donor-specific immunologic unresponsiveness in xenotransplantation using genetically modified, histocompatible inbred pigs. Project 1 optimizes xenotransplantation tolerance in human immune system mice by combining porcine thymus transplantation with xenogeneic mixed hematopoietic chimerism, characterizing immune mechanisms and conditioning regimens for translation to large animal models. Project 2 advances thymus and kidney composite grafts in non-human primates to achieve xenotransplantation without maintenance immunosuppression, building on demonstrated long-term survival of genetically altered porcine kidney grafts. The research aims to eliminate the severe toxic side effects associated with current heavy immunosuppression regimens used in xenotransplantation. Work is performed in New York, New York. The award funds research through June 30, 2031.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $3.0m | 7/21/26 |