Project Grant P01AI181994
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Johns Hopkins University a $1.03 million Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) for the period September 2, 2025 through August 31, 2030. This research initiative addresses clinically relevant pharmacologic and immunomodulatory strategies to achieve long-term survival of kidney xenografts in primates. The project builds on recent advances...
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $444,125 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025 through July 31, 2027. The award supports investigator-initiated biomedical research focused on developing and evaluating therapeutic interventions for xenotransplantation rejection. Specifically, the...
- Federal Cooperative Agreement Summary New York University School of Medicine received a $2.86 million Cooperative Agreement from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded July 1, 2025, with a completion date of May 31, 2030. The award funds research applying genomics and omics technologies to advance pig-to-human xenotransplantation outcomes. The project leverages NYU Langone's innovative...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded $492,250 under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the Terasaki Institute for Biomedical Innovation on February 2, 2026, for a project period extending through January 31, 2028. The award funds the development of a vascularized porcine liver on-a-chip (VPLOC) platform designed to model human xenoimmune responses to porcine liver xenografts. This microfluidic...
- Federal Grant Award Summary New York University School of Medicine received a $1.72 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on April 20, 2026, with completion targeted for March 31, 2033. This multicenter clinical trial, known as the HOPE Heart Study, will evaluate the safety and efficacy of HIV-to-HIV heart transplantation (HIV D+/R+ transplants) across 25...
- Federal Project Grant Award Summary New York University School of Medicine received a $806,693 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective June 12, 2025, with a completion date of May 31, 2030. The award supports investigator-initiated biomedical research focused on understanding the role of lymphatic vasculature in regulating germinal center responses and...
- Federal Project Grant Award Summary New York University School of Medicine received a $466,125 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective August 1, 2025, through July 31, 2027. The award funds research to elucidate the molecular mechanisms of orthopoxvirus entry, specifically examining the critical initial interactions between viral and human cellular proteins...
- Federal Grant Award Summary New York University School of Medicine received a $791,797 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective February 4, 2026, through January 31, 2031. The research initiative, titled "Intestinal Programming of Gut-Associated Germinal Centers," investigates the mechanisms by which the intestinal microbiota directs B cell responses and...
- Federal Grant Award Summary Georgetown University received a $429,000 Project Grant from the National Institute of Allergy and Infectious Diseases under the Allergy and Infectious Diseases Research program (CFDA 93.855), effective July 1, 2025, through June 30, 2027. The grant funds a two-year research project to evaluate cell-type-specific injury markers in liver allografts during normothermic machine perfusion (NMP). The research will investigate whether cell-free methylated DNA (cfDNA)...
- Federal Grant Award Summary New York University received a $470,028 Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded on August 21, 2025, with a completion date of July 31, 2030. This award supports investigator-initiated biomedical research focused on deciphering fungal pathogen-specific cell cycle mechanisms to advance antifungal drug discovery. The research specifically targets...
Federal Grant Award Summary New York University School of Medicine received a $2.06 million Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), awarded April 15, 2026, with completion scheduled for March 31, 2031. The award funds research utilizing an innovative pig-to-human decedent xenotransplantation model to advance clinical xenotransplantation trials. The primary deliverables include conducting 20 thymokidney xenotransplants in human decedents and monitoring clinical, immunological, and physiological outcomes for up to 60 days post-transplant to characterize the human adaptive immune response to xenografts for the first time. The research program consists of four integrated projects designed to fill critical knowledge gaps before human clinical xenotransplantation trials commence. Project deliverables will include: identification of optimal immunosuppression regimens and source animal genetics; comprehensive characterization of humoral and cellular immune responses to xenografts in humans; and evaluation of pig kidney physiologic function in human recipients. Building on preliminary data from five prior decedent xenotransplants, the research will employ multi-omic profiling approaches and provide critical clinical management experience with xenograft recipients, directly supporting the advancement of xenotransplantation toward clinical viability as a solution to organ transplant shortage.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $2.1m | 4/17/26 |