This Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) to Brigham & Women's Hospital totals $4,506,493 over 5 years to study age-related changes in alloimmune responses and transplant immunity. The award supports three complementary research projects that will:
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Examine how cellular senescence in lymph node stromal cells drives divergent immune responses in aging and impacts the efficacy of co-stimulatory blockade therapies.
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Investigate age-specific changes in innate and T cell immunity that rewire allorecognition, T cell metabolism, and immunosuppressive targets, with a focus on senolytic treatments.
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Elucidate how aging alters transcriptional programming in T follicular helper (Tfh) and B cells, undermining antibody-mediated rejection therapies.
The award includes sub-grants to the University of Maryland, Baltimore to collect and analyze lymph node samples, and to Harvard Medical School to provide metabolomic expertise and services. This research aims to advance the understanding of age-related immunological mechanisms and develop more effective transplant therapies for older recipients.
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