Project Grant K99NS150648
- The National Institutes of Health's National Institute of Neurological Disorders and Stroke awarded The Ohio State University a $119,018 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders program. This grant will support research into strategies to interrogate and enhance myelin remodeling in distal tissue after spinal cord injury. The goal of the NINDS program is to fund basic and applied research exploring the brain, nervous system structure...
- The National Institute of Neurological Disorders and Stroke, an operating division of the Department of Health and Human Services National Institutes of Health, awarded The Ohio State University $611,634 on May 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate age-associated expansion of natural IgM FCRL5+ B cell clones as drivers of progressive multiple sclerosis and potential therapeutic targets. The research...
- The National Institute of Neurological Disorders and Stroke (NINDS), a component of the Department of Health and Human Services National Institutes of Health, awarded $646,936 to the Regents of the University of California, San Francisco on June 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853, Project Grant R01NS142318). The award funds research investigating the inflammatory mechanisms underlying motor and sensory...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services, awarded The Ohio State University $424,333 on September 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop a bioengineered blood-brain barrier-on-a-chip microphysiological system for improved drug screening in primary brain tumors. The project addresses the challenge of modeling glioblastoma cellular...
- The National Institute of General Medical Sciences, part of the National Institutes of Health within the Department of Health and Human Services, awarded The Ohio State University $433,125 on June 1, 2026, under the Biomedical Research and Research Training program (CFDA 93.859) to investigate metabolic reprogramming in reparative macrophages and its role in wound healing. The project examines how metabolic shifts in macrophages—specifically through the serine synthesis pathway component...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $642,712 to The University of Texas Southwestern Medical Center on June 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate adult neurogenesis as a strategy for improving urinary function after contusion spinal cord injury. The project systematically examines...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded $544,568 to Cleveland Clinic Lerner College of Medicine of Case Western Reserve University on February 11, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to investigate the pathogenesis of permanent neurological disability in multiple sclerosis. The research identifies cellular...
- The National Institute of Neurological Disorders and Stroke, part of the Department of Health and Human Services National Institutes of Health, awarded The Medical University of South Carolina $226,500 on August 21, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to characterize spinal pain and non-pain pathway activity and responses in people with chronic spinal cord injury and neuropathic pain. The research will compare...
- The National Institute of Neurological Disorders and Stroke, part of the National Institutes of Health, awarded The Ohio State University $180,240 on February 1, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853). The award funds research into the mechanisms by which the neuronal TRPM2 ion channel affects post-stroke cognitive impairment. The project uses genetic animal models and adeno-associated viruses to conditionally knockout...
- The National Institute of Neurological Disorders and Stroke awarded The Washington University $245,874 on July 2, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to develop therapies that reprogram astrocytes to promote neural repair following spinal cord injury. The research defines pro-regenerative glial cell reactivity in zebrafish, performs an in vivo CRISPR screen to identify transcription regulators of that reactivity,...
The National Institute of Neurological Disorders and Stroke, a division of the Department of Health and Human Services National Institutes of Health, awarded The Ohio State University $124,298 on August 15, 2026, under the Extramural Research Programs in the Neurosciences and Neurological Disorders program (CFDA 93.853) to define stage-specific roles of macrophages in spinal cord repair. The work investigates how microglia and monocyte-derived macrophages contribute to spinal cord injury progression and recovery across acute, subacute, and chronic phases. The recipient will use temporally restricted ablation to pinpoint when macrophage activity benefits or harms repair and how microglia modulate macrophage pathogenicity. The project will also assess transcriptomic differences between neonatal and adult macrophages following injury, selectively ablate osteopontin signaling in monocyte-lineage cells, and test whether suppression of this pathway permits macrophage clearance, reduces scarring, and improves functional recovery. The research addresses the hypothesis that persistent macrophage presence driven by prolonged osteopontin signaling and maladaptive microglia-macrophage cross-talk acts as a barrier to regeneration following spinal cord injury. Performance occurs at Columbus, Ohio. The period of performance runs through July 31, 2028. The award is classified as a Project Grant, the standard assistance type for NINDS extramural research.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $124.3k | 8/7/26 |