Project Grant K99NS142573
- This federal Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, provides $124,485 to The Leland Stanford Junior University (Stanford University) to develop and test a "Fused Imaging and Large Language Foundational Model (FILLM)" to predict 90-day outcomes for patients with acute ischemic strokes. The project aims to integrate...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $423,500 Project Grant (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders) to the Augusta University Research Institute, Inc. The objective is to develop and evaluate engineered exosomes carrying neuron-targeting peptides and a therapeutic protein (neuroglobin) for treating ischemic stroke. The research will: 1) characterize the engineered exosomes and assess their...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $541,109 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the University of Washington. The 5-year grant, beginning January 1, 2025, will fund research to quantify myelin loss and recovery in ischemic stroke patients using a novel magnetic resonance imaging (MRI) technique called single-point macromolecular proton fraction (MPF) mapping. The...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $299,982 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to Unandup, LLC, a technology development firm in St. Louis, Missouri. The grant funding supports the development of the Commercialization Readiness Pilot for the FAST (Flow Acceleration for Stroke Thrombolysis) System, an innovative medical device platform designed to safely accelerate the...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a $385,500 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). This 2-year grant, effective February 1, 2025, will support the development of an inducible and multiplexed dual gene modulation CRISPR system to study neuronal activity and regeneration. The goal is to create a synthetic biology...
- The National Institute of Neurological Disorders and Stroke (NINDS) awarded a Project Grant of $1,375,478 under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to the J. David Gladstone Institutes in California. This grant funding supports a multidisciplinary research program to study the role of neurovascular dysfunction in neurodegeneration, CNS repair, and glial cell biology. Key research activities include in vivo two-photon and super-resolution...
- This $520,025 Project Grant award, provided by the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, aims to develop new peptide nucleic acid (PNA) inhibitors targeting the miR-141-3p microRNA for potential stroke therapy. The research focuses on synthesizing and characterizing more potent gamma-PNA (GPNA) analogs of the miR-141-3p inhibitor, with the primary goal of...
- This $490,049 Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, supports research by Shearit LLC to evaluate the efficacy of their Lamiflo drug for reducing ischemic penumbra and core volumes in acute ischemic stroke. The 1-year study will test Lamiflo, a drag-reducing polymer that enhances blood flow, in rat models of middle cerebral artery...
- This Project Grant award of $192,500 from the National Institute of Neurological Disorders and Stroke (NINDS) under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program supports research to define the contribution of endothelial cell sphingolipid metabolism to outcomes of acute ischemic stroke in mice. The award, effective December 1, 2024, will enable the University of Utah to leverage innovative murine models and novel ceramide biosynthesis...
- This federal Project Grant award of $664,458, provided by the National Institute of Neurological Disorders and Stroke (CFDA 93.853 - Extramural Research Programs in the Neurosciences and Neurological Disorders), supports research to develop a novel non-invasive optical imaging technique for the prehospital detection of large vessel occlusion (LVO) in acute stroke patients. The University of Pennsylvania, the grant recipient, is validating this optical cerebral hemodynamic monitoring approach...
The U.S. National Institute of Neurological Disorders and Stroke (NINDS) awarded a $125,685 Project Grant under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) to The Leland Stanford Junior University (Stanford University). The funding will support the development of an injectable hydrogel with an integrated urokinase plasminogen activator (uPA) motif and plasmid DNA (pDNA) platelet-derived growth factor B (PDGFB)-lipoplexes to be loaded into the gel. The goal is to restore neurovascular integrity and function following ischemic stroke in order to prevent the development of post-stroke dementia, which affects 7 million stroke survivors in the U.S. The award period runs from August 9, 2025 to July 31, 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.7k | 8/8/25 |