Project Grant K99HL177415
- This federal Project Grant award, provided by the National Heart Lung and Blood Institute under the Cardiovascular Diseases Research program (CFDA 93.837), supports a research project at Brigham & Women's Hospital Inc. to better understand changes in the pulmonary vasculature and their relationship to lung parenchyma using advanced CT imaging in patients with pulmonary hypertension and chronic obstructive pulmonary disease (COPD). The $812,189 award, with a project period from May 1, 2025 to...
- The Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $268,500 to Brigham & Women's Hospital Inc. to develop and validate a quantitative marker of pulmonary microvascular injury and explore the correlation between microvascular volume loss and the longitudinal progression of chronic obstructive pulmonary disease (COPD) and emphysema in smokers. The research leverages an AI-based algorithm to assess vascular...
- This Cooperative Agreement award from the National Heart, Lung, and Blood Institute (NHLBI), under the Cardiovascular Diseases Research program (CFDA 93.837), will develop new pulmonary magnetic resonance imaging (MRI) methods on a novel 0.55 Tesla scanner. The $659,644 project, running from September 2025 to June 2029, will focus on improving the spatial resolution and image contrast of structural lung proton MRI, as well as developing methodology for hyperpolarized xenon imaging at this...
- This $116,625 federal Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) will characterize clinically relevant phenotypes related to osteoporosis and sarcopenia in chronic obstructive pulmonary disease (COPD). The project will develop automated methods to derive static metrics of spine, vertebrae, and pectoral muscles, as well as dynamic metrics of lung diaphragmatic surface deformation, from chest CT scans. It will then use...
- This federal Project Grant award of $429,000.00 from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) aims to develop an efficient, contrast-free, 3D whole-lung low-field magnetic resonance imaging (MRI) protocol for the detection of pulmonary embolism (PE). The project, awarded to the Regents of the University of Michigan, will leverage advancements in low-field MRI hardware and deep learning techniques to create a rapid, comfortable, and radiation-free...
- This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $684,814 to The Regents of the University of California, San Francisco (UCSF) to conduct research on the suppression of alveolar stem cells by tissue-resident lymphocytes in emphysema. The research aims to investigate how tissue factors in the lung alter the inflammatory response to viral infections, leading to the loss of alveolar type 2...
- This federal Project Grant award from the National Institute of Biomedical Imaging and Bioengineering (NIBIB), under the Discovery and Applied Research for Technological Innovations to Improve Human Health program (CFDA 93.286), provides $150,951 to the University of Texas at Austin (UT Austin) to develop a novel computational lung breathing model for robust lung function assessment. The goal is to leverage this biomechanical lung model to infer patient-specific lung tissue material properties...
- This Project Grant award from the National Heart Lung and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) provides $708,063 in funding to the University of Virginia for a research project titled "Post-Transcriptional Regulatory Networks in Chronic Obstructive Pulmonary Disease". The goal of the 5-year project is to generate RNA-binding protein (RBP) regulatory networks, identify COPD-specific changes, and characterize the functional consequences of the network changes....
- The University of Southern California (USC) Department of Contracts and Grants Division received a $413,958 Project Grant from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837). The purpose of this 1-year award, effective September 22, 2023, is to investigate the role of the protein PUMA in promoting cell death and inflammation in chronic obstructive pulmonary disease (COPD) caused by cigarette smoke exposure. The research aims...
- This $1,831,848 Project Grant award from the National Heart, Lung, and Blood Institute (CFDA 93.837 Cardiovascular Diseases Research) supports research to investigate how early-life disruptions to gut microbiota colonization can remodel the development of lung immune and epithelial cells, contributing to chronic respiratory diseases. The research aims to identify the critical window and key microbial taxa required for establishing long-term lung homeostasis. Preliminary data indicates that...
This Project Grant award of $108,003.00, provided by the National Heart Lung and Blood Institute under CFDA Program 93.837 Cardiovascular Diseases Research, supports a study on "Early Changes of T2* Measures in Lung Tissues Using Deltate-UTE MRI on Healthy and COPD Patients" at the University of California, San Diego (UCSD). The goal is to develop an advanced ultrashort echo-time (UTE) magnetic resonance imaging (MRI) technique, called TE-UTE, to accurately map T2* values in lung parenchyma and detect early microstructural changes in the lungs of patients with Chronic Obstructive Pulmonary Disease (COPD). The award has an initial period of performance from August 15, 2025 to May 31, 2027. This research aims to provide a non-invasive diagnostic approach to assess lung health without the risks associated with ionizing radiation, which is critical for the growing population of COPD patients globally.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $108.0k | 8/12/25 |