This Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) provides $165,364 to The Broad Institute, Inc. to integrate novel blood pressure measures with genomics to enhance cardiovascular disease (CVD) prediction and management in young adults aged 18-39 years. The key products and services to be delivered under this 2-year project include:
Identification of novel ambulatory blood pressure patterns using machine learning approaches to capture dynamic responses to environmental factors.
Development of a multi-ancestry genetic risk score to project long-term blood pressure trajectories and inform optimal timing of antihypertensive treatment.
Creation of an individualized CVD risk prediction model integrating genomic and non-genomic risk factors, accounting for time-updated treatment status, and applicable starting at age 18.
This research aims to leverage multiethnic cohorts, large-scale genomics, and real-world healthcare data to accurately estimate short- and long-term CVD risk earlier in life and facilitate earlier clinical interventions for young adults.