Project Grant K99GM160701
- This federal Project Grant award of $404,058.00 from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), supports a research project focused on investigating the mechanisms that regulate the formation of crossovers on meiotic chromosomes. The research aims to use single-molecule imaging techniques to understand how the dynamics of proteins that control crossover formation create coordinated patterns along...
- The National Institute of General Medical Sciences (NIGMS) awarded a $415,520 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the College of William & Mary. This 3-year grant supports research to investigate the genetic basis of virulence traits in opportunistic fungal pathogens and how these traits may arise through "accidental virulence" or "coincidental selection" in the environment. The research will screen over 1,000...
- This $362,340 Project Grant award from the National Human Genome Research Institute (CFDA 93.172 - Human Genome Research) supports research to identify genes that shape complex multigenic traits within and between yeast species. The objectives are to apply a new genetic mapping method called CRI-SPA-MAP to discover causal genes that influence the ability of yeast strains to grow in diverse environmental conditions. The research will be conducted at the University of Minnesota from August 2025 to...
- The University of California, Merced received a $550,108 Project Grant award under the National Institute of General Medical Sciences' (NIGMS) Biomedical Research and Research Training program (CFDA 93.859) to conduct fundamental research on the genetic regulation of microbial community formation, with a focus on biofilms. The project, which runs from May 5, 2025 to March 31, 2030, aims to provide new insights into the molecular and mechanistic bases of biofilm development, regulation, and...
- This federal Project Grant award of $227,435, awarded on August 1, 2025 by the National Institute of General Medical Sciences (NIGMS), provides funding for research on "Genetic Constraints on Adaptive Evolution" under the Biomedical Research and Research Training program (CFDA 93.859). The goal of the research program is to unravel how genetic constraints limit adaptation and how these constraints diverge between species. The University of Rochester, the awardee, will build on their...
- The National Institute of General Medical Sciences (NIGMS) awarded a $376,498 Project Grant under the Biomedical Research and Research Training program (CFDA 93.859) to the University of California, San Diego (UCSD) for a 5-year research program from August 1, 2025 to July 31, 2030. The research will focus on developing new active genetic systems that can function in both germline and somatic cell contexts. This includes exploring the use of CRISPR-based gene drive systems to potentially...
- The federal Project Grant award of $420,066.00 from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) will fund research to systematically characterize how regulatory networks control secondary metabolism in microbes. The project aims to use genome-wide screens and multi-omics approaches to predict and access the unexplored biosynthetic potential of microbes, with the goal of accelerating the discovery,...
- This federal Project Grant award of $188,627, awarded by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), funds the development of tools to measure post-translational modification enzyme activity, with a focus on kinases. The project aims to (1) build understanding of kinase-substrate interactions using techniques like in vitro phosphoproteomics, novel substrate design, and computational methods, and (2) develop...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), provides $318,956.00 to the Regents of the University of Minnesota for the period of September 1, 2025 to June 30, 2030. The overarching goal of this research is to improve the generalizability of genetics research to diverse populations, in order to better understand the genetic basis of complex diseases. The grant will support...
- The National Institute of General Medical Sciences (NIGMS) awarded a $361,952 project grant under the Biomedical Research and Research Training program (CFDA 93.859) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant supports research to systematically explore the mutational landscape of biomedically relevant proteins such as CRISPR-Cas genome editing enzymes. The goal is to develop experimental methods and machine...
The National Institute of General Medical Sciences (NIGMS), under the Biomedical Research and Research Training program (CFDA 93.859), awarded a $125,000 Project Grant to the Regents of the University of Minnesota for the period of September 1, 2025 to August 31, 2027. The goal of this research project is to investigate the impacts of copy number variation on gene regulatory networks and fitness in the fungal pathogen Candida albicans. The project aims to: 1) Test the fitness effects of gene overexpression in multiple genetic backgrounds and environments using CRISPR-activation technology, 2) Model transcriptional regulatory networks by combining CRISPR-activation with single-cell RNA-sequencing to identify genome-wide transcriptional effects of gene amplification, and 3) Use experimental evolution to explore how a gene's position within the regulatory network influences the rate and dynamics of the evolution of antifungal drug resistance. This research is expected to contribute to a better understanding of evolutionary principles in microorganisms, which can inform efforts to combat the emergence of antimicrobial drug resistance.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $125.0k | 8/27/25 |