This Project Grant awarded by the National Institute of General Medical Sciences (NIGMS), under CFDA 93.859 Biomedical Research and Research Training Program, provides $410,000.00 in funding to The Trustees of Princeton University from September 1, 2024 to June 30, 2029. The award supports the university's theoretical and computational research to uncover the molecular determinants of biomolecular condensate compositional control and assembly mechanisms. The research program leverages...
This federal Project Grant award of $438,629, issued by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859), supports research to characterize fundamental mechano-molecular mechanisms of cell division. The research, conducted by the University of Massachusetts, will combine advanced live-cell imaging, molecular, and biochemical methods to investigate two key areas: the functional contributions of extremely large...
The National Institute of General Medical Sciences (NIGMS) awarded a $222,708 Project Grant to the Regents of the University of Michigan under the Biomedical Research and Research Training program (CFDA 93.859). The grant, awarded on May 7, 2025, will fund research to determine the mechanisms by which specific subsets of microtubules are selected for post-translational modifications that regulate critical cellular processes such as intracellular trafficking and cell migration. The research...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training Program (CFDA 93.859) provides $410,000.00 to The Trustees of Princeton University to develop advanced computational models to characterize the molecular structures and interactions within biomolecular condensates, with a focus on stress granules. The research aims to: 1) map the structures of RNA-binding proteins to stress granule properties, 2)...
This National Science Foundation Project Grant of $740,498 will support research titled "TRANSITIONS: A UNIFIED CELLULAR AND IN VITRO APPROACH TO DISCOVER MOLECULAR MECHANISMS OF MICROTUBULE DYNAMICS AND REGULATION" from January 15, 2023 through December 31, 2025. The principal investigator at the University of Texas Southwestern Medical Center will receive training in modern genetics and imaging methods to study microtubules, which provide structure and shape to eukaryotic cells....
The University of Texas Southwestern Medical Center was awarded a $651,001 Project Grant by the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859). The funding supports research to advance the understanding of the structural and biochemical mechanisms underlying microtubule dynamics and regulation. The research aims to reveal the allosteric logic of the tubulin conformation cycle, provide new biochemical insights...
The National Institutes of Health's National Institute of General Medical Sciences (CFDA 93.859 Biomedical Research and Research Training Program) awarded a $1,286,156 Project Grant to The Trustees of the University of Pennsylvania for the project "Cytokinesis and the Septin Cytoskeleton." The 5-year project, running from September 1, 2024 to August 31, 2029, will use an integrative research approach to address key questions about the architecture and constriction mechanism of the...
The National Science Foundation awarded a $565,000 Project Grant to Princeton University from May 2021 through April 2024 under the Biological Sciences federal grant program (CFDA 47.074). This funding supports comparative analysis of endocytic trafficking during cell division through collaborative research. The goal of the Biological Sciences program is to promote progress in the biological sciences and strengthen the nation's scientific enterprise by increasing knowledge and understanding of...
This three-year, $719,144 project grant from the National Science Foundation's Mathematical and Physical Sciences program (CFDA 47.049) supports research at Rensselaer Polytechnic Institute to develop a mesoscale kinetic theory framework for early mitotic spindle organization. The framework will use statistical summaries and parameterization through in vitro experiments to model crosslinker-mediated interactions between microtubules during cell division. Researchers will construct a reduced...
This Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $492,000.00 to The Trustees of Princeton University over a 5-year period from September 1, 2024 to August 31, 2029. The funding will support research aimed at accessing and expanding the chemical space of microbial and microbiome natural products. Key objectives include: (1) eliciting cryptic metabolites from diverse microbial genera,...
This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) Biomedical Research and Research Training Program (CFDA 93.859) provides $125,000 in funding to The Trustees of Princeton University to conduct research on microtubule nucleation and its role in cellular architecture and function.
The key objectives of this 2-year award are to: 1) determine how branched microtubule networks assemble into a functional mitotic spindle during early cell division; and 2) identify the factors involved in acentrosomal microtubule nucleation that contribute to the formation of elaborate dendritic structures in neurons. The research will use in vitro reconstitution and targeted RNAi screening approaches to elucidate the molecular mechanisms underlying microtubule organization in these critical cellular processes. Findings from this work are expected to substantially advance the understanding of how microtubule dynamics and organization drive cellular architecture and function.