The Icahn School of Medicine at Mount Sinai (ISMMS) has been awarded a $126,985 Project Grant from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) federal grant program. This 2-year grant will support research to investigate the impact of ambient environmental pollutants on vaccine antibody response and immune cell function in children. The project will leverage the ongoing PROGRESS cohort study in Mexico City to: 1) develop new exposure models for ozone, 2) assess associations between multiple pollutants and vaccine antibody levels, 3) evaluate the impact of pollutants on immune cell populations, and 4) examine if immune cell changes mediate the relationship between pollutants and antibody response. This research aims to expand understanding of how environmental exposures influence immune function and infectious disease susceptibility, which is a critical public health issue highlighted by the COVID-19 pandemic. The grant supports the awardee's training and development to become an independent investigator in this interdisciplinary field at the intersection of environmental health, immunology, and infectious disease.