Project Grant K99DE035132
- This $476,287 federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will fund research to investigate the role of the MERTK receptor tyrosine kinase in promoting alveolar bone regeneration after tooth extraction. The primary objectives are to determine the effects of MERTK signaling on resident alveolar bone stem cells and the recruitment and phenotype of immune cells in the...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), awarded a $270,594 Project Grant to Greenmark Biomedical Inc. on Sep 1, 2025. The grant supports the development of nano-fluorapatite particles to directly fill subsurface enamel pores, with the goal of halting the progression of non-cavitated carious lesions without requiring multiple remineralization treatments. Preliminary data demonstrates the ability of...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $421,800 Project Grant under the Oral Diseases and Disorders Research program (CFDA 93.121) to Midwestern University. The purpose of this 3-year grant, with a start date of September 7, 2023, is to develop hybrid hydrogel-based dental adhesives that are less vulnerable to hydrolytic degradation compared to current methacrylate-based alternatives. The goal is to create a truly biomimetic dental adhesive that can not only...
- The federal Project Grant award in the amount of $613,736 was provided by the National Institute of Dental and Craniofacial Research (NIDCR), which administers the Oral Diseases and Disorders Research federal grant program (CFDA 93.121). The grant was awarded to Cayman Chemical Co Inc., a for-profit company located in Ann Arbor, Michigan, to develop novel osteogenic small-molecule pharmacotherapies for dental bone regeneration. Specifically, Cayman Chemical will create novel EZH2 inhibitor...
- This federal Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research program (CFDA 93.121), will provide $429,000.00 to the Regents of the University of Michigan to conduct research on the unique characteristics of jawbone biology. The research aims to gain a molecular-level understanding of how osteoblasts in the jawbone respond differently to bone morphogenetic protein (BMP) signaling and mechanical loading...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $298,942 Project Grant to Deltamed LLC on August 20, 2025. The grant funding will support the development of a novel "nanosponge prodrug delivery system" for the small molecule MK2 inhibitors apatinib and MMI-0100. The goal is to improve the circulation half-life and targeted delivery of these compounds to mitigate...
- This Project Grant award from the Department of Health and Human Services' National Institutes of Health (NIH) Trans-NIH Research Support program (CFDA 93.310) provides $445,703 to the Regents of the University of Michigan to conduct research on "Multiparametric Characterization of Periodontal Tissues for Inflammation Monitoring Using Quantitative Ultrasound, Texture Analysis and Machine Learning." The research aims to establish ultrasound-derived quantitative biomarkers and a...
- The National Institute of Dental and Craniofacial Research (NIDCR) awarded a $294,632 Project Grant under the Oral Diseases and Disorders Research (CFDA 93.121) program to Greenmark Biomedical Inc. in East Lansing, Michigan. The project aims to develop an intraoral imaging system that uses targeted nanoparticle-enhanced fluorescent technology and artificial intelligence (AI) algorithms to improve early detection and monitoring of dental caries (tooth decay). Specifically, the project involves...
- The National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121), awarded a $913,000 Project Grant to the University of Southern California to support research on periodontal regeneration using supramolecular nanomaterials. The project aims to identify biologically active peptides, specifically the leucine-rich amelogenin peptide (LRAP), that can stimulate the differentiation of periodontal ligament cells...
- This $408,375 Project Grant award from the National Institute of Dental and Craniofacial Research (NIDCR), under the Oral Diseases and Disorders Research (CFDA 93.121) program, supports the development of a novel "Biomimetic Nitric Oxide and Hydroxyapatite Duo" for advanced direct pulp capping. The key products and services to be delivered through this 2-year award include: Characterization of the physical-mechanical properties of a Hydroxyapatite-fortified Peptide Amphiphile (PA-HA)...
The University of Michigan received a $135,000 Project Grant from the National Institute of Dental and Craniofacial Research (NIDCR) under the Oral Diseases and Disorders Research federal grant program (CFDA 93.121) to develop bioinspired synthetic high-density lipoprotein (SHDL) nanotherapeutics with immunomodulatory and regenerative potential for treating endodontic conditions. The 2-year grant project, which started on August 1, 2025, aims to identify a non-toxic SHDL-antibiotic formulation with enhanced antimicrobial and immunomodulatory properties, investigate its mechanisms and pathways for treating necrotic mature permanent teeth with apical periodontitis in rats, and determine the nanoparticles' ability to promote pulp and dentin regeneration and root formation in rats with partial or fully necrotic immature permanent teeth.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $135.0k | 7/29/25 |