This $112,026 Project Grant award from the National Cancer Institute's Cancer Research Manpower program (CFDA 93.398) will support research by the University of Texas MD Anderson Cancer Center to investigate the role of the oral microbiome in the development and progression of brain metastases.
Specifically, the research will elucidate the mechanisms underlying the formation of an orally-derived tumor microbiome in brain metastases and determine the local and systemic contributions of the oral microbiota to brain metastasis using longitudinal clinical studies and mouse models. The insights gained from this work have the potential to inform the development of new diagnostic, preventive, and therapeutic strategies for metastatic brain tumors. The research will be conducted under the mentorship of leading experts in microbiome, cancer immunology, and brain metastasis research at MD Anderson Cancer Center.
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