This $123,409 Project Grant award from the National Cancer Institute (CFDA 93.398 - Cancer Research Manpower program) supports research at Northwestern University to investigate the role of the protein Gasdermin D in the bone marrow microenvironment during the progression of clonal hematopoiesis (CH), a pre-malignant condition that elevates the risk of hematologic malignancies. The project aims to employ mouse models and a novel 3D human bone marrow organoid system to elucidate how inflammation from non-hematopoietic stromal cells contributes to CH progression, and how Gasdermin D deficiency mitigates this process. Spatial transcriptomic and single-cell RNA sequencing analyses will be used to uncover the underlying cellular and molecular mechanisms. The research will lay the groundwork for potential therapeutic strategies targeting dysregulated inflammation in the bone marrow microenvironment. The award period runs from February 1, 2025 to January 31, 2027.
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