This federal Project Grant award from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), under the Arthritis, Musculoskeletal and Skin Diseases Research program (CFDA 93.846), provides $230,212.00 to Rockefeller University to explore how immune cells and stem cells interact within the skin tissue microenvironment.
The key objectives are to: 1) determine how direct contact between dendritic epidermal T cells and hair follicle stem cells mediates functional stem cell specification within the hair follicle, and 2) investigate how proximity to lymphoid clusters across the skin tissue dictates spatial and functional stem cell heterogeneity among different hair follicles. The results are expected to provide new insights into the role of the immune system in regulating skin stem cell functions and homeostasis, which has implications for understanding disease mechanisms. The award began on Jul 15, 2024 and is scheduled for completion by Aug 31, 2026.
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