Project Grant K08AI194971
- This federal Project Grant award for $711,993.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), will support research to examine the effects of Mycobacterium tuberculosis (MTB) disease on HIV-1 pathogenesis in people living with HIV (PWH). The research aims to assess how MTB disease influences the development of broadly neutralizing HIV-1 antibodies, the emergence of NAb-resistant viral...
- This $193,375 Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to identify bacterial determinants that may contribute to variable treatment responses for tuberculosis (TB). The project, conducted by researchers at the Harvard T.H. Chan School of Public Health, aims to investigate the effects of clinically prevalent variants in the ESX1 secretion system on TB...
- This Project Grant award of $104,262, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to explore the relationship between genetic variants, transcriptional responses, and tuberculosis (TB) infection outcomes in macrophages derived from genetically diverse mice. The project aims to understand the basis for variability in TB infection outcomes, which may help identify ways to...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a 5-year, $1,640,492 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Albert Einstein College of Medicine to study the role of the ESX5 secretome of Mycobacterium tuberculosis in TB and TB-HIV pathogenesis and immunity. The researchers generated a genetic deletion of the ESX5 locus, which they found produced a live attenuated vaccine that is highly effective at preventing TB in...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to leverage antibody-omics to prevent and detect tuberculosis (TB) in children affected by HIV. The $209,750 award supports research to define antibody features associated with protection from Mycobacterium tuberculosis (MTB) infection among HIV-exposed infants (Aim 1) and identify biomarkers for active TB and MTB...
- The Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, was awarded a $135,540 federal Project Grant from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) to conduct research focused on the development of long-acting injectable delivery systems for antiretroviral therapy to prevent and treat HIV/AIDS. The grant, awarded on September 3, 2025, will support the recipient's...
- This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, will support research to investigate the use of chest radiography (CXR) to identify young individuals with early stages of tuberculosis (TB) in a community-based active case-finding program in Lima, Peru. The $242,376 award to Brigham & Women's Hospital Inc., a subsidiary of Partners Healthcare System, will fund a 2-year study to...
- The U.S. National Institute of Allergy and Infectious Diseases (NIAID) awarded a $1,166,933 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to Vanderbilt University Medical Center to study Mycobacterium tuberculosis transmission. The project aims to identify bacterial genetic and phenotypic features associated with M. tuberculosis transmission outcomes, including infection, subclinical TB, and clinical TB disease. It will also define M. tuberculosis...
- This $1,173,748.00 Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), will fund research on the role of asymptomatic tuberculosis (TB) in disease transmission. The research aims to improve understanding of when individuals become infectious and where transmission is occurring, particularly in community settings outside of household contacts. Key areas of focus include characterizing...
- This $781,369 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research (CFDA 93.855) federal grant program. The funding supports research to investigate the role of B cells in regulating lung inflammation and disease progression in chronic tuberculosis (TB). The research aims to elucidate how B cells drive CD4+ T cell expansion and pro-inflammatory responses, as well as how B cells may restrict...
This Project Grant, awarded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $194,400 in funding to Brigham & Women's Hospital Inc. to conduct research on the role of antibody-dependent innate effector function in tuberculosis (TB) disease progression among individuals co-infected with HIV. The 5-year research program aims to comprehensively investigate how perturbations to antibody-mediated effector functions contribute to the increased risk of TB progression in HIV co-infected individuals. The research will leverage plasma samples from two international cohorts to 1) evaluate the impact of HIV on the breadth of Fc-mediated antibody effector functions, and 2) define antibody-dependent functional correlates that predict TB progression and Mycobacterium tuberculosis antimicrobial control in the setting of HIV co-infection. The project is being carried out by Brigham & Women's Hospital Inc., a subsidiary of the larger Partners Healthcare System, a prominent academic medical center and research institution in Boston, Massachusetts.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $194.4k | 9/11/25 |