Project Grant K99AG088300
- This federal Project Grant award of $442,938, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research at the University of California, San Francisco (UCSF) to investigate the relationship between sleep, memory, and aging. The key objectives are to: 1) characterize how aging affects sleep patterns required for memory consolidation and synaptic plasticity during long-term memory formation; and 2) determine how upregulating the unfolded protein response can...
- This federal Project Grant award of $101,915 from the National Institute on Aging (CFDA 93.866 - Aging Research) is funding research to investigate the impacts of pharmacological slow wave sleep enhancement on cognition and memory in an Alzheimer's disease (AD) mouse model. The study, led by researchers at Columbia University, will use two drug compounds, gaboxadol and trazadone, to assess whether enhancing slow wave activity can normalize sleep-wake disturbances, reduce amyloid plaque burden,...
- This federal Project Grant award of $125,000.00, provided by the National Institute on Aging (CFDA 93.866 Aging Research), supports research to investigate the relationship between sleep loss and neurodegeneration. The grantee, The Washington University, will use the funding to examine how sleep deprivation can epigenetically alter microglial responses to tau protein aggregates, which is a key pathological feature of Alzheimer's disease and other tauopathies. The research aims to identify...
- The National Institute on Aging (NIA) awarded a $785,348 project grant (CFDA 93.866 - Aging Research) to The Salk Institute for Biological Studies in La Jolla, California. The project, titled "Chronic Sleep Disruption is a Stressor for Healthspan and Lifespan", will investigate the biological mechanisms by which chronic sleep disruption (CSD) may interact with the aging process to increase the risk of age-related diseases. The research aims to determine if long-term CSD affects the...
- This federal Project Grant award from the National Institute of Mental Health (NIMH) under the Mental Health Research Grants program (CFDA 93.242) provides $665,893 to the Regents of the University of Michigan to conduct research on how hippocampal activity during sleep supports the stabilization and isolation of context-specific memories. The key products and services to be delivered under this 5-year award include: 1) developing advanced machine learning techniques to study the evolution of...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $684,924 to Northwestern University to conduct research on the relationship between the noradrenergic (NA) system, sleep quality, and cognitive function in older adults with insomnia. The project aims to systematically characterize central and peripheral measures of the NA system and assess their association with sleep quality and cognitive performance in older adults with insomnia, as well as...
- This Project Grant from the National Institute on Aging, part of the Department of Health and Human Services, will fund research into the molecular interplay of sleep and neurodegeneration using the Drosophila model system. With $2.14 million provided over 11 months, the Trustees of the University of Pennsylvania will investigate how expression of the TDP-43 protein linked to neurodegenerative diseases disrupts sleep in fruit flies. Researchers will aim to define the specific glial subtypes...
- This $612,005 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to characterize sleep slow-wave activity (SWA) and its relationship to chronic stress, accelerated aging, and Alzheimer's disease in a cohort of 200 Black older adults aged 55-80 in the United States. The award will support ambulatory overnight sleep monitoring, biomarker assessments, and cognitive testing to examine how chronic stress impacts SWA and its association with markers of...
- This Project Grant award, funded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), provides $420,750 to Washington State University to investigate the complex interactions between aging, transcriptional processing, protein aggregation, sleep disturbance, and cognitive decline in an Alzheimer's disease rat model. The researchers will leverage innovative techniques, such as the use of single-chain variable fragments to evaluate protein oligomerization,...
- The National Institute on Aging (NIA) awarded Brigham & Women's Hospital Inc. a $2,576,936 Project Grant under the Aging Research federal grant program (CFDA 93.866) to characterize the variability in sleep spindle activity across a population and evaluate the use of sleep spindle dynamics as biomarkers for Alzheimer's disease, mild cognitive impairment, and trisomy 21. The 3-year project will develop statistical models and methods to analyze sleep spindle patterns and their relationship...
This federal Project Grant award of $107,097.00 was provided by the National Institute on Aging (NIA) under the Aging Research grant program (CFDA 93.866) to the Regents of the University of Michigan. The overall objective is to test the hypothesis that age-related sleep disturbances alter the activity and connectivity of hippocampal somatostatin-expressing (SST+) interneurons, leading to memory impairments. The award will fund research to quantify the structure, function, and gene expression of hippocampal SST+ cells in aged versus adult mice, and evaluate whether partial chronic sleep deprivation or a sleep-promoting treatment can worsen or rescue these aging-related phenotypes. This research aims to elucidate the link between sleep disturbances and memory problems that arise during aging, with the goal of informing potential interventions to address these debilitating health concerns in the aging population.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $107.1k | 9/16/25 |