This $125,896 federal Project Grant award from the National Institute on Aging (NIH, CFDA 93.866 Aging Research) to The Washington University is focused on performing genetic and single-cell multi-omic characterization of Alzheimer's disease (AD) risk and resilience pathways.
The key objectives are to: 1) dissect non-coding AD genetic risk through multi-omic profiling of healthy and AD brain tissue, 2) identify protective mechanisms in cognitively healthy older adults and centenarians, and 3) characterize the interplay between caloric restriction and neurodegeneration in AD mouse models. This innovative, multifaceted approach aims to provide deeper insights into the molecular pathways underlying AD risk and resilience, with the potential to inform novel AD prevention strategies. The award period runs from July 2024 through June 2026 and supports the mentored research and training of the principal investigator under the guidance of several senior co-mentors.