This $132,300 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by the Scripps Research Institute to investigate the role of the protein PTP1B in Alzheimer's disease pathophysiology and its relationship to sleep disturbances. The key objectives are to determine whether inhibiting PTP1B can improve sleep patterns, neuropathology, and cognitive performance in Alzheimer's disease mouse models, as well as to identify the genetic targets and brain regions modulated by the PTP1B inhibitor CX08005. The award covers a 2-year project period from May 1, 2024 to April 30, 2026. This work aims to advance the understanding of the molecular mechanisms linking sleep regulation to Alzheimer's disease progression, with the goal of identifying new therapeutic targets and strategies.
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