This $112,875 federal Project Grant award, funded by the National Institute on Aging under the Aging Research program (CFDA 93.866), will support research at the University of Wisconsin - Madison to investigate the mechanistic role of dietary protein in aging and Alzheimer's disease.
The research aims to define the metabolic and molecular interactions between dietary restrictions, such as protein or isoleucine restriction, and the life-extending drug rapamycin. It will leverage mouse models to dissect the mechanisms by which dietary protein levels impact lifespan, healthspan, and cognitive function, with a focus on understanding the regulation of lipolysis and brain lipid profiles. The ultimate goal is to advance the understanding of how dietary protein contributes to the biology of aging and the development of Alzheimer's disease pathogenesis. The award period runs from July 1, 2024 to June 30, 2026.
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