This federal Project Grant award of $756,077, provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports a 5-year research study on the long-term immunologic, cardiovascular, metabolic, and neurocognitive consequences of inflammation in children with perinatal HIV in sub-Saharan Africa. The primary objectives are to assess the durability of inflammation and immune...
This federal Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,314,701.00 to support research focused on optimizing dolutegravir-based antiretroviral therapy (ART) in children and adolescents. The primary award recipient is the University of Florida, which will oversee the overall research project. The project includes sub-awards to Kwame Nkrumah University of Science...
This federal Project Grant award, funded by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $884,322 to support research into the mechanisms that create and sustain the HIV reservoir - a population of latently infected cells that persists during suppressive antiretroviral therapy and prevents a cure for HIV. The research team, led by Dr. Reeves and collaborators at the Fred Hutchinson Cancer...
The Fogarty International Center (FIC), part of the U.S. Department of Health and Human Services National Institutes of Health, awarded a $268,665 Project Grant (CFDA 93.989 - International Research and Research Training) to the Joint Clinical Research Centre in Uganda. The grant, titled "LEVERAGING NORTH-SOUTH PARTNERSHIPS TO ADVANCE CELL AND GENE THERAPY FOR HIV RESEARCH TRAINING CAPACITY IN UGANDA (C AND GT-UGANDA)," aims to build research and training capacity for cell and gene...
This $100,720 Project Grant awarded by the Fogarty International Center (CFDA 93.989 - International Research and Research Training) aims to strengthen the capacity of the African Center of Excellence in Bioinformatics and Data Intensive Sciences (ACE) in Uganda to support HIV research. The grant will fund the training of four local staff in high-performance computing (HPC) competencies at the Texas Advanced Computing Center, enabling them to implement HPC system improvements and integrate HPC...
This Project Grant award for $1,314,572.00, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research aimed at developing a cure strategy for HIV-1 using CD4-mimetic compounds (CD4MCs) and CD4-induced antibodies (CD4I Abs). The research, conducted by Yale University, leverages the recent discovery of a new class of indoline CD4MCs that display improved antiviral potency and breadth...
This Project Grant award from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), provides $1,332,155 to Emory University to conduct research focused on developing immunotherapies to cure HIV in SHIV-infected infant macaques. The key objectives are to evaluate strategies that leverage broadly neutralizing antibodies (bNAbs) in combination with virus reactivation, innate immune stimulation, and attachment...
This $775,391 federal Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to investigate the role of the human protein galectin-9 in HIV persistence and the establishment of the long-term viral reservoir. The primary awardee, Vitalant Research Institute, will conduct in vitro studies to elucidate the molecular and immunological mechanisms underlying galectin-9's impact on the HIV reservoir. Additionally,...
This $244,814 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will fund a mixed-methods research study to investigate the social and behavioral drivers of HIV risk among South African adolescent girls and young women (SA-AGYW). The primary objectives are to: 1) conduct secondary analyses of baseline data from an existing HIV prevention intervention to examine the roles of mental health...
This federal Project Grant award, provided by the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855), aims to elucidate the molecular mechanisms underlying T cell dysfunction and HIV persistence in persons with HIV (PWH). The $500,000 award, effective from September 1, 2024 to August 31, 2029, will support research conducted by The General Hospital Corporation (Massachusetts General Hospital) to identify and...